Seroprevalence of Kaposi's sarcoma-associated herpesvirus in healthy adults in Israel

Jose Iscovich, Alf Fischbein, Jocheved Fisher-Fischbein, Laurence S. Freedman, Sybil M. Eng, Paolo Boffetta, Alex Vudovich, Cyril Glasman, Reuven Goldschmidt, Martine Livingston, Billa Heger-Maslansky, Paul Brennan, Patrick S. Moore

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

To determine if Kaposi's sarcoma-associated herpesvirus (KSHV) prevalence is correlated with the 9-fold difference in the incidence of classic Kaposi's sarcoma observed among Israeli Jewish populations, we conducted a cross-sectional KSHV seroprevalence survey in a population of 166 HIV-seronegative healthy subjects from the general population (26 women, 140 men). Eight individuals (4.8%) (all men) were seropositive for KSHV differences between men and women were not statistically significant. If we consider the sensitivity and specificity of the assays, the corrected prevalence would be 6.1% (95% confidence interval 2.0-10.1). We noticed a non-statistically 5.5-fold difference between individuals above and below 40 years of age, but did not find an association with the incidence of classic KS among the Israeli Jewish sub-population, according to their origin. This suggests that KSHV is only necessary, albeit not sufficient, cause of classic Kaposi's sarcoma.

Original languageEnglish
Pages (from-to)2119-2122
Number of pages4
JournalAnticancer Research
Volume20
Issue number3 B
StatePublished - 2000

Keywords

  • Classic Kaposi's sarcoma
  • Incidence
  • Israel
  • Kaposi's sarcoma human virus
  • Sere-prevalence

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