TY - JOUR
T1 - Seroprevalence of Kaposi's sarcoma-associated herpesvirus in healthy adults in Israel
AU - Iscovich, Jose
AU - Fischbein, Alf
AU - Fisher-Fischbein, Jocheved
AU - Freedman, Laurence S.
AU - Eng, Sybil M.
AU - Boffetta, Paolo
AU - Vudovich, Alex
AU - Glasman, Cyril
AU - Goldschmidt, Reuven
AU - Livingston, Martine
AU - Heger-Maslansky, Billa
AU - Brennan, Paul
AU - Moore, Patrick S.
PY - 2000
Y1 - 2000
N2 - To determine if Kaposi's sarcoma-associated herpesvirus (KSHV) prevalence is correlated with the 9-fold difference in the incidence of classic Kaposi's sarcoma observed among Israeli Jewish populations, we conducted a cross-sectional KSHV seroprevalence survey in a population of 166 HIV-seronegative healthy subjects from the general population (26 women, 140 men). Eight individuals (4.8%) (all men) were seropositive for KSHV differences between men and women were not statistically significant. If we consider the sensitivity and specificity of the assays, the corrected prevalence would be 6.1% (95% confidence interval 2.0-10.1). We noticed a non-statistically 5.5-fold difference between individuals above and below 40 years of age, but did not find an association with the incidence of classic KS among the Israeli Jewish sub-population, according to their origin. This suggests that KSHV is only necessary, albeit not sufficient, cause of classic Kaposi's sarcoma.
AB - To determine if Kaposi's sarcoma-associated herpesvirus (KSHV) prevalence is correlated with the 9-fold difference in the incidence of classic Kaposi's sarcoma observed among Israeli Jewish populations, we conducted a cross-sectional KSHV seroprevalence survey in a population of 166 HIV-seronegative healthy subjects from the general population (26 women, 140 men). Eight individuals (4.8%) (all men) were seropositive for KSHV differences between men and women were not statistically significant. If we consider the sensitivity and specificity of the assays, the corrected prevalence would be 6.1% (95% confidence interval 2.0-10.1). We noticed a non-statistically 5.5-fold difference between individuals above and below 40 years of age, but did not find an association with the incidence of classic KS among the Israeli Jewish sub-population, according to their origin. This suggests that KSHV is only necessary, albeit not sufficient, cause of classic Kaposi's sarcoma.
KW - Classic Kaposi's sarcoma
KW - Incidence
KW - Israel
KW - Kaposi's sarcoma human virus
KW - Sere-prevalence
UR - http://www.scopus.com/inward/record.url?scp=0033869817&partnerID=8YFLogxK
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C2 - 10928163
AN - SCOPUS:0033869817
SN - 0250-7005
VL - 20
SP - 2119
EP - 2122
JO - Anticancer Research
JF - Anticancer Research
IS - 3 B
ER -