Sequence based identification of RNA editing sites

Eli Eisenberg, Jin Billy Li, Erez Y. Levanon

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

RNA editing diversifies the human transcriptome beyond the genomic repertoire. Recent years have proven a strategy based on genomics and computational sequence analysis as a powerful tool for identification and characterization of RNA editing. In particular, analysis of the human transcriptome has resulted in the identification of thousands of A-to-I editing sites within genomic repeats, as well as a few hundred sites located outside repeats. We review these recent advancements, emphasizing the principles underlying the various methods used. Possible directions for extending these methods are discussed.

Original languageEnglish
Pages (from-to)248-252
Number of pages5
JournalRNA Biology
Volume7
Issue number2
DOIs
StatePublished - 2010

Keywords

  • A-to-I RNA-editing
  • Alu repeats
  • Bioinformatics
  • Human genome
  • Next-generation sequencing

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