Sensing the penetration of nanodiamond along different skin layers according to their optical properties

Channa Shapira, Ariel Foraiter, Israel Messenberg, Hamootal Duadi, Dror Fixler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Imaging in opaque media is limited in spatial resolution. Therefore, detection of nanoelements that are behind the imaging resolution limit is challenging. In this work, we used the iterative multiplane optical properties extraction (IMOPE) technique to detect nanoparticles (NP) within the different skin layers. The IMOPE technique was originally designed for detecting NPs in turbid environment based on their scattering property. However, the scattering depends on the size of the particle, therefore detecting extremely small particles, with negligible scattering, was still a challenge for the IMOPE technique. In our work, we adapted the IMOPE technique to detect nanodiamonds (ND) as such, with negligible scattering but nonnegligible absorption, inside the different layers of the skin. In the following manuscript we present an extension of the automated technique, that is more robust and applicable to non-symmetrical samples.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XX
EditorsDror Fixler, Ewa M. Goldys, Sebastian Wachsmann-Hogiu
PublisherSPIE
ISBN (Electronic)9781510658936
DOIs
StatePublished - 2023
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XX 2023 - San Francisco, United States
Duration: 30 Jan 2023 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12394
ISSN (Print)1605-7422

Conference

ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XX 2023
Country/TerritoryUnited States
CitySan Francisco
Period30/01/23 → …

Bibliographical note

Publisher Copyright:
© 2023 SPIE.

Keywords

  • Gerchberg-Saxton algorithm
  • Nanodiamonds
  • Phase reconstruction
  • Sensing

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