Semisynthetic Cephalosporins. Synthesis and Structure-Activity Relationships 7-(l-Pyrryl)- and 7-(l-Indolyl)acetamidocephalosporin Derivatives

A. Nudelman, H. Karoly, F. Braun, E. H.W. Böhme, R. C. Erickson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A series of l-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. The most active compound in the series was 7-[[2-(l-pyrryl)acetyl]amino]-3-[[(l-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against Enterobacter sp. and Providencia stuarti.

Original languageEnglish
Pages (from-to)962-964
Number of pages3
JournalJournal of Medicinal Chemistry
Volume21
Issue number9
DOIs
StatePublished - 1978
Externally publishedYes

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