Abstract
A series of l-pyrrole- and 1-indoleacetamido derivatives of 3-heteroaryl-substituted cephalosporins was prepared. The most active compound in the series was 7-[[2-(l-pyrryl)acetyl]amino]-3-[[(l-methyltetrazol-5-yl)thio]-methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6), which showed comparable potency in vitro and in vivo to that of cefazolin, and, in addition, was more potent than cefazolin against Enterobacter sp. and Providencia stuarti.
Original language | English |
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Pages (from-to) | 962-964 |
Number of pages | 3 |
Journal | Journal of Medicinal Chemistry |
Volume | 21 |
Issue number | 9 |
DOIs | |
State | Published - 1978 |
Externally published | Yes |