TY - JOUR
T1 - Semisynthetic cephalosporins. IV synthesis and structure activity relationships of parenterally active 7-[4-(substituted methyl)phenyl]-acetamido-3-cephem-4-carboxylic acids
AU - Nudelman, Abraham
AU - Haviv, Fortuna
AU - Patchornick, Abraham
AU - Karoly-Hafely, Eva
AU - Braun-Bucholts, Frida
AU - Kaier, Batia
AU - Itzchaki, Judith
AU - Sasson, Sabar
AU - Erickson, Raymond C.
PY - 1981/10
Y1 - 1981/10
N2 - A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino-Δ-3-cephems to afford a family of parenterally active cephalosporins. A compound designated 131 had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 131 included high potency against penicillinase-producing staphylococci and activity against anaerobes, including Bacteroides fragilis.
AB - A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino-Δ-3-cephems to afford a family of parenterally active cephalosporins. A compound designated 131 had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 131 included high potency against penicillinase-producing staphylococci and activity against anaerobes, including Bacteroides fragilis.
UR - http://www.scopus.com/inward/record.url?scp=0019845762&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.34.1311
DO - 10.7164/antibiotics.34.1311
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C2 - 7309625
AN - SCOPUS:0019845762
SN - 0021-8820
VL - 34
SP - 1311
EP - 1317
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 10
ER -