TY - JOUR
T1 - Semisynthetic cephalosporins. III1) synthesis and structure activity relationships of novel orally active 7-[4-hydroxy-3-(substituted methyl)phenyl]-acetamido-3-cephem-4-carboxylic acids
AU - Nudelman, Abraham
AU - Patchornick, Abraham
AU - Karoly-Hafely, Eva
AU - Braun, Frida
AU - Erickson, Raymond C.
PY - 1980/1
Y1 - 1980/1
N2 - A family of novel optically active α-amino-3-substituted-methyl-4-hydroxy benzene acetic acids (3) have been prepared. A number of these amino acids were converted to a group of cephalosporins (12). Compound 12A showed the most interesting activity in vitro and in vivo, primarily against Gram-positive organisms and was shown to be well absorbed orally.
AB - A family of novel optically active α-amino-3-substituted-methyl-4-hydroxy benzene acetic acids (3) have been prepared. A number of these amino acids were converted to a group of cephalosporins (12). Compound 12A showed the most interesting activity in vitro and in vivo, primarily against Gram-positive organisms and was shown to be well absorbed orally.
UR - http://www.scopus.com/inward/record.url?scp=0019274277&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.33.76
DO - 10.7164/antibiotics.33.76
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C2 - 7372553
AN - SCOPUS:0019274277
SN - 0021-8820
VL - 33
SP - 76
EP - 82
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 1
ER -