Self-Assembly in Protein-Based Bionanomaterials

Aleksei Solomonov, Ulyana Shimanovich

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Supramolecular self-assembled structures, based on protein−protein interactions, have garnered widespread interest as prospective functional bionanomaterials. Possessing unique properties, proteins have been widely investigated in the last years, due to their capability to form a diversity of natural and artificially designed zero-, one-, two- and three-dimensional assemblies. These structures laid the basis for bionanomaterials design, including films, foams, gels, and others, with widespread applications in electronics, biomedicine, and environmental sciences. In this context, the present review is devoted to revealing the diversity of protein assemblies and related bionanomaterials. Special interest is paid to recent advances and new trends in functional amyloids and fibrillar silk-based self-assembling architectures, as well as their current and potential applications. We emphasize the protein nanostructures’ diversity for the future design of functional protein-based materials.

Original languageEnglish
Pages (from-to)1152-1170
Number of pages19
JournalIsrael Journal of Chemistry
Issue number12
StatePublished - Dec 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


This work was supported by the Scholarship Program for Research Students from The Ministry of Aliyah and Integration of the State of Israel (A. S.), the Ruth and Herman Albert family, Gruber Foundation, the Nella and Leon Benoziyo Centre for Neurological diseases (U. S.), Schwartz/Reisman Foundation (U. S.), Yad Hanadiv (U. S.) and the Israeli Council for Higher Education-Alon fellowship (U. S.). This research is made possible in part by the historic generosity of the Harold Perlman Family. The authors are grateful to Steve Manch for editing the manuscript.

FundersFunder number
Israeli Council for Higher Education-Alon
Ministry of Aliyah and Integration of the State of Israel
Ruth and Herman Albert family
Schwartz/Reisman Foundation
Gruber Foundation


    • amyloids
    • functional bionanomaterials
    • proteins
    • self-assembly
    • silk


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