Selective modulation by vitamin D of renal response to parathyroid hormone: A study in calcitriol-resistant rickets

Lea Even, Yosef Weisman, David Goldray, Ze'ev Hochberg

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Calcitriol-resistant rickets (CRR) is an autosomal recessive disease caused by mutated nonfunctioning vitamin D receptors. Because of their lack of biological activity of vitamin D, CRR patients were studied to investigate whether vitamin D modulates the effects of PTH on renal tubules. Five patients with CRR and three controls were studied. After normalization of serum calcium, phosphorus, and PTH levels by oral and iv administration of calcium, exogenous PTH-(1-34) was infused, and timed fractions of urine were collected for measurements of cAMP, sodium, potassium, phosphorus, calcium, and bicarbonate. Serum 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] was measured before and after PTH-(1-34) infusion. Urinary cAMP and fractional excretion of potassium, phosphorus, and bicarbonate were similar in CRR patients and controls, as was the rise in the serum 1,25-(OH)2D3 concentration after PTH-(1-34) infusion. However, urinary excretion of calcium and sodium decreased after PTH-(1-34) infusion in controls, but not in CRR patients. These results suggest a selective modulation by vitamin D of the renal response to PTH; 1,25-(OH)2D3 facilitates PTH-induced calcium and sodium reabsorption, but does not influence PTH-induced cAMP excretion; phosphorus, potassium, and bicarbonate tubular transport, or 1α- hydroxylation of 25-hydroxyvitamin D3.

Original languageEnglish
Pages (from-to)2836-2840
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number8
StatePublished - Aug 1996
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements We thank Marie-Pierre Dufief and Paul Demaret for technical assistance and Michelle Plasch for secretarial assistance. This work was supported by the Belgian National Fund for Scientific Research (F.N.R.S.), the Research Fund of the University of Brussels (U.L.B.), and the Banque Nationale de Belgique. B. Dan is supported by the Fondation Van Goethem-Brichant and the Fondation Lekime-Ropsy.


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