Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Lina Tsaadon Alon; Shmuel Pietrokovski; Shay Barkan; Limor Avrahami; Oksana Kaidanovich-Beilin; James R. Woodgett; Anat Barnea; Hagit Eldar-Finkelman

doi:10.1016/j.febslet.2011.03.025

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Lina Tsaadon Alon, Shmuel Pietrokovski, Shay Barkan, Limor Avrahami, Oksana Kaidanovich-Beilin, James R. Woodgett, Anat Barnea, Hagit Eldar-Finkelman

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Mammalian glycogen synthase kinase-3 (GSK-3), a critical regulator in neuronal signaling, cognition, and behavior, exists as two isozymes GSK-3α and GSK-3β. Their distinct biological functions remains largely unknown. Here, we examined the evolutionary significance of each of these isozymes. Surprisingly, we found that unlike other vertebrates that harbor both GSK-3 genes, the GSK-3α gene is missing in birds. GSK-3-mediated tau phosphorylation was significantly lower in adult bird brains than in mouse brains, a phenomenon that was reproduced in GSK-3α knockout mouse brains. Tau phosphorylation was detected in brains from bird embryos suggesting that GSK-3 isozymes play distinct roles in tau phosphorylation during development. Birds are natural GSK-3α knockout organisms and may serve as a novel model to study the distinct functions of GSK-3 isozymes.

Original language	English
Pages (from-to)	1158-1162
Number of pages	5
Journal	FEBS Letters
Volume	585
Issue number	8
DOIs	https://doi.org/10.1016/j.febslet.2011.03.025
State	Published - 20 Apr 2011
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by FP7 EU Grant #223276 “NeuroGSK3” and the Israeli Academy of Sciences , Grant #341/10 . JR Woodgett acknowledge Grant CIHR MOP#74711. We thank Dr. Tal Pupko for helpful discussions. We apologize to investigators whose work could not be cited because of space limitations.

Funding

This work was supported by FP7 EU Grant #223276 “NeuroGSK3” and the Israeli Academy of Sciences , Grant #341/10 . JR Woodgett acknowledge Grant CIHR MOP#74711. We thank Dr. Tal Pupko for helpful discussions. We apologize to investigators whose work could not be cited because of space limitations.

Funders	Funder number
FP7 EU
Israeli Academy of Sciences	341/10
Seventh Framework Programme	223276

Keywords

Bird
Brain
Evolution
GSK-3
Tau phosphorylation

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10.1016/j.febslet.2011.03.025

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abstract = "Mammalian glycogen synthase kinase-3 (GSK-3), a critical regulator in neuronal signaling, cognition, and behavior, exists as two isozymes GSK-3α and GSK-3β. Their distinct biological functions remains largely unknown. Here, we examined the evolutionary significance of each of these isozymes. Surprisingly, we found that unlike other vertebrates that harbor both GSK-3 genes, the GSK-3α gene is missing in birds. GSK-3-mediated tau phosphorylation was significantly lower in adult bird brains than in mouse brains, a phenomenon that was reproduced in GSK-3α knockout mouse brains. Tau phosphorylation was detected in brains from bird embryos suggesting that GSK-3 isozymes play distinct roles in tau phosphorylation during development. Birds are natural GSK-3α knockout organisms and may serve as a novel model to study the distinct functions of GSK-3 isozymes.",

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AU - Kaidanovich-Beilin, Oksana

AU - Woodgett, James R.

AU - Barnea, Anat

AU - Eldar-Finkelman, Hagit

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Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Abstract

Bibliographical note

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Keywords

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