Seizure frequency and characteristics in children with Down syndrome

Hadassa Goldberg-Stern, Richard H. Strawsburg, Bonnie Patterson, Fran Hickey, Mary Bare, Natan Gadoth, Ton J. Degrauw

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Seizures have not historically been considered a major component of Down syndrome. We examined the prevalence of epileptic seizures in 350 children and adolescents with Down syndrome evaluated at a regional center between 1985 and 1997. Results showed that 28 patients (8%) had epileptic seizures: 13 (47%) partial seizures; 9 (32%) infantile spasms, and 6 (21%) generalized tonic-clonic seizures. In the infantile spasm group, there was no relationship between the initial electroencephalogram (EEG) pattern and response to treatment or long-term seizure control, or between type of pharmacologic treatment (valproic acid, adrenocorticotropic hormone or both) and clinical remission, EEG normalization or long-term seizure control. Neurodevelopmental outcome was poor despite good seizure control in the infantile spasm group. This regional study reinforces the relative association of seizures and Down syndrome. A prospective study including a national/international registry with emphasis on developmental assessment and long-term follow up is warranted.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalBrain and Development
Issue number6
StatePublished - 2001
Externally publishedYes


  • Down syndrome
  • Infantile spasm
  • Prevalence
  • Prognosis
  • Seizure


Dive into the research topics of 'Seizure frequency and characteristics in children with Down syndrome'. Together they form a unique fingerprint.

Cite this