Schizophrenia, chronic hospitalization and the 5-HT(2C) receptor gene

R. H. Segman, R. P. Ebstein, U. Heresco-Levy, M. Gorfine, M. Avnon, E. Gur, L. Nemanov, B. Lerer

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Frequency of a polymorphism in the coding region of the 5-hydroxytryptamine(2C) (5-HT(2C)) receptor gene (HTR2C Xq24) was not significantly different in 122 unrelated Israeli schizophrenia patients compared with 180 control subjects matched for gender and ethnicity. However, proportion of time spent in hospital since the first admission was significantly greater in patients hemi- or homozygous for the 5-HT(2Cser) allele than in patients carrying other genotypes (p = 0.006). The 5-HT(2Cser) genotype conferred a 3.3-fold increased risk for lifetime hospitalization exceeding 10 years. Genetically determined variation in the 5-HT(2C) receptor may influence the clinical course and phenotypic expression of schizophrenia.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalPsychiatric Genetics
Issue number2
StatePublished - 1997
Externally publishedYes


  • 5-HT(2c) receptor polymorphism
  • Chronic hospitalization
  • Genetic association
  • Schizophrenia
  • Serotonin


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