TY - JOUR
T1 - Sanctuary of hepatitis B virus in bone-marrow cells of patients undergoing liver transplantation
AU - Ilan, Y.
AU - Galun, E.
AU - Nagler, A.
AU - Baruch, Y.
AU - Livni, N.
AU - Tur-Kaspa, R.
PY - 1996/5
Y1 - 1996/5
N2 - Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV is mainly a hepatotrophic virus but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent liver transplantation. Both underwent bone marrow (BM) and liver biopsies after transplantation. Biopsy specimens were stained for hepatitis B surface antigen (HBsAg), and bone marrow aspirates and were separated for all subsets of cells. In both cases, HBV DNA analysis detected DNA in all BM fractions after transplantation, but HBV recurrence was found only in one case. We suggest that graft reinfection after liver transplantation may be caused by active replication of HBV in extrahepatic tissues and that BM cells are probably one of the major sanctuaries. The use of immunoprophylaxis based on BM-HBV studies is discussed.
AB - Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV is mainly a hepatotrophic virus but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent liver transplantation. Both underwent bone marrow (BM) and liver biopsies after transplantation. Biopsy specimens were stained for hepatitis B surface antigen (HBsAg), and bone marrow aspirates and were separated for all subsets of cells. In both cases, HBV DNA analysis detected DNA in all BM fractions after transplantation, but HBV recurrence was found only in one case. We suggest that graft reinfection after liver transplantation may be caused by active replication of HBV in extrahepatic tissues and that BM cells are probably one of the major sanctuaries. The use of immunoprophylaxis based on BM-HBV studies is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0029966122&partnerID=8YFLogxK
U2 - 10.1002/lt.500020306
DO - 10.1002/lt.500020306
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C2 - 9346650
SN - 1074-3022
VL - 2
SP - 206
EP - 210
JO - Liver Transplantation and Surgery
JF - Liver Transplantation and Surgery
IS - 3
ER -