Abstract
Extant research has documented the effects of intranasal administration of oxytocin (OT), and to a lesser degree Arginine Vasopressin (AVP)-two structurally-related neuropeptides-on brain and behaviour, yet the effects of exogenous manipulation of one on circulating levels of the other remain unknown. Studies have shown that OT administration impacts the peripheral levels of numerous hormones; however, whether OT administration also increases AVP concentrations has not been explored. Utilizing a double-blind placebo-controlled within-subject design, ten male and female subjects provided ten saliva samples over four consecutive hours: at baseline and nine times following OT administration. Results indicate that salivary AVP increased in the first hour following OT manipulation (OT condition: mean AVP = 2.17 pg/ml, SE = 28, placebo condition: mean AVP = 1.42 pg/ml, SE =.18) but returned to baseline levels at the next assessment (80 min) and remained low for the remaining period. Similar to OT, AVP showed high degree of individual stability and baseline levels of AVP correlated with AVP concentrations at the first and second post-administration hours regardless of drug condition (Pearson r =.85-.93). Validity of salivary AVP ELISA measurement was verified by demonstrating individual stability of salivary AVP over a six-month period (r =.70, p <.000) as well correlation with plasma levels over the same period (r =.32, p =.037) in a sample of 45 young adults who did not participate in the current study. Overall, findings suggest a potential crosstalk between OT and AVP and indicate that baseline levels of the two neuropeptides may shape the degree to which these systems respond to exogenous manipulation.
Original language | English |
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Pages (from-to) | 99-103 |
Number of pages | 5 |
Journal | Peptides |
Volume | 40 |
DOIs | |
State | Published - Feb 2013 |
Bibliographical note
Funding Information:Research at Dr. Feldman's laboratory during the study period was supported by the Israel Science Foundation (1318/08), the US-Israel Bi-National Science Foundation (2005-273), the NARSAD foundation (independent investigator award, 2006, 2008), the Katz Family Foundation , the Kor Family Foundation , and the Irving B. Harris Foundation .
Funding
Research at Dr. Feldman's laboratory during the study period was supported by the Israel Science Foundation (1318/08), the US-Israel Bi-National Science Foundation (2005-273), the NARSAD foundation (independent investigator award, 2006, 2008), the Katz Family Foundation , the Kor Family Foundation , and the Irving B. Harris Foundation .
Funders | Funder number |
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Irving B. Harris Foundation | |
Katz Family Foundation | |
Kor Family Foundation | |
NARSAD Foundation | |
US-Israel bi-national Science Foundation | 2005-273 |
Israel Science Foundation | 1318/08 |
Keywords
- AVP
- CSF
- CV
- ELISA
- IU
- OT
- PVN
- SEM
- SON
- arginine vasopressin
- cerebrospinal fluid
- coefficient variance
- enzyme immunoassay
- international units
- oxytocin
- paraventricular nuclei
- standard error mean
- supraoptic nuclei