TY - JOUR
T1 - Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia
T2 - An-Open Label, Add-On, Pilot Study
AU - Shelef, Assaf
AU - Barak, Yoram
AU - Berger, Uri
AU - Paleacu, Diana
AU - Tadger, Shelly
AU - Plopsky, Igor
AU - Baruch, Yehuda
N1 - Publisher Copyright:
© 2016 - IOS Press and the authors. All rights reserved.
PY - 2016/2/27
Y1 - 2016/2/27
N2 - Background: Tetrahydrocannabinol (THC) is a potential treatment for Alzheimer's disease (AD). Objective: To measure efficacy and safety of medical cannabis oil (MCO) containing THC as an add-on to pharmacotherapy,in relieving behavioral and psychological symptoms of dementia (BPSD). Methods: Eleven AD patients were recruited to an open label, 4 weeks, prospective trial. Results: Ten patients completed the trial. Significant reduction in CGI severity score (6.5 to 5.7; p < 0.01) and NPI score were recorded (44.4 to 12.8; p < 0.01). NPI domains of significant decrease were: Delusions, agitation/aggression, irritability, apathy, sleep and caregiver distress. Conclusion: Adding MCO to AD patients' pharmacotherapy is safe and a promising treatment option.
AB - Background: Tetrahydrocannabinol (THC) is a potential treatment for Alzheimer's disease (AD). Objective: To measure efficacy and safety of medical cannabis oil (MCO) containing THC as an add-on to pharmacotherapy,in relieving behavioral and psychological symptoms of dementia (BPSD). Methods: Eleven AD patients were recruited to an open label, 4 weeks, prospective trial. Results: Ten patients completed the trial. Significant reduction in CGI severity score (6.5 to 5.7; p < 0.01) and NPI score were recorded (44.4 to 12.8; p < 0.01). NPI domains of significant decrease were: Delusions, agitation/aggression, irritability, apathy, sleep and caregiver distress. Conclusion: Adding MCO to AD patients' pharmacotherapy is safe and a promising treatment option.
KW - Alzheimer's disease
KW - behavioral and psychological symptoms of dementia
KW - cannabis
KW - tetrahydrocannabinol
UR - http://www.scopus.com/inward/record.url?scp=84960107999&partnerID=8YFLogxK
U2 - 10.3233/JAD-150915
DO - 10.3233/JAD-150915
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C2 - 26757043
AN - SCOPUS:84960107999
SN - 1387-2877
VL - 51
SP - 15
EP - 19
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -
