TY - PAT
T1 - S-substituted 1,3,7-trialkyl-xanthine derivatives
AU - Jacobson, Kenneth A.
AU - Karton, Yishai
AU - Gallo-Rodriguez, Carola
AU - Fischer, Bilha
AU - Galen, Philip J. M. van
AU - Maillard, Michel
PY - 1999
Y1 - 1999
N2 - The present invention provides 8-substituted 1,3,7-trialkylxanthines useful as A2 -selective adenosine receptor antagonists and compositions comprising such compounds. Examples of the 8-substituted 1,3,7-trialkyl xanthines include: ##STR1## In compound (a), R1, R3, and R7 are methyl and X is one to three substituents, which may be the same or different and selected from the group consisting of amino, C1 -C4 alkylcarbonylamino, carboxy C2 -C4 alkylcarbonylamino, halo, C1 -C3 alkyloxy, amino C1 -C4 alkyloxy, C1 -C4 alkyloxy carbonylamino, amino C1 -C4 alkenyloxy, isothiocyanato, and diazonium tetrafluoroborate. In compound (b), R1, R3, and R7 are methyl, R.sub.β is hydrogen or methyl, and X is selected from the group consisting of R, C(═O)OR, and C(═O)NH--R, wherein R is a C1 -C6 alkyl.
AB - The present invention provides 8-substituted 1,3,7-trialkylxanthines useful as A2 -selective adenosine receptor antagonists and compositions comprising such compounds. Examples of the 8-substituted 1,3,7-trialkyl xanthines include: ##STR1## In compound (a), R1, R3, and R7 are methyl and X is one to three substituents, which may be the same or different and selected from the group consisting of amino, C1 -C4 alkylcarbonylamino, carboxy C2 -C4 alkylcarbonylamino, halo, C1 -C3 alkyloxy, amino C1 -C4 alkyloxy, C1 -C4 alkyloxy carbonylamino, amino C1 -C4 alkenyloxy, isothiocyanato, and diazonium tetrafluoroborate. In compound (b), R1, R3, and R7 are methyl, R.sub.β is hydrogen or methyl, and X is selected from the group consisting of R, C(═O)OR, and C(═O)NH--R, wherein R is a C1 -C6 alkyl.
UR - https://patents.google.com/patent/US5861405A/en
M3 - Patent
M1 - US5861405A
PB - US Department of Health and Human Services (HHS)
ER -