Ruthenium-catalyzed site-selective C-H bond activation/annulation cascade toward dibenzoazepinone skeletons

Deepan Chowdhury, Suman Dana, Subhankar Maity, Mahiuddin Baidya

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

A free amine-directed ruthenium(II)-catalyzed hydroarylation and concomitant regioselective transamidation cascade between 2-aminobiphenyls and diversely substituted maleimides is reported, furnishing biologically relevant dibenzo[b,d]azepinone scaffolds in high yields. The protocol accommodates a range of functional groups and showcases synthesis of dibenzoazepinones bearing amino acid side chains through substrate design.

Original languageEnglish
Pages (from-to)6760-6764
Number of pages5
JournalOrganic Letters
Volume22
Issue number17
DOIs
StatePublished - 4 Sep 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2020 American Chemical Society.

Funding

The authors gratefully acknowledge DST-SERB, India (CRG/2019/001003), for financial support. D.C. and S.D. acknowledge IIT Madras for providing the HTRA fellowship. M.B. thanks IIT Madras for the Institute Research Development Award (IRDA).

FundersFunder number
DST-SERBCRG/2019/001003
IIT Madras
Indian Institute of Technology Madras

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