Ruthenium-catalyzed site-selective C-H bond activation/annulation cascade toward dibenzoazepinone skeletons

Deepan Chowdhury, Suman Dana, Subhankar Maity, Mahiuddin Baidya

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31 Scopus citations


A free amine-directed ruthenium(II)-catalyzed hydroarylation and concomitant regioselective transamidation cascade between 2-aminobiphenyls and diversely substituted maleimides is reported, furnishing biologically relevant dibenzo[b,d]azepinone scaffolds in high yields. The protocol accommodates a range of functional groups and showcases synthesis of dibenzoazepinones bearing amino acid side chains through substrate design.

Original languageEnglish
Pages (from-to)6760-6764
Number of pages5
JournalOrganic Letters
Issue number17
StatePublished - 4 Sep 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2020 American Chemical Society.


The authors gratefully acknowledge DST-SERB, India (CRG/2019/001003), for financial support. D.C. and S.D. acknowledge IIT Madras for providing the HTRA fellowship. M.B. thanks IIT Madras for the Institute Research Development Award (IRDA).

FundersFunder number
IIT Madras
Indian Institute of Technology Madras


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