Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI

Alon Erdman, Rany Abend, Itamar Jalon, Moran Artzi, Tomer Gazit, Keren Avirame, Ezequiel Diego Ais, Hilik Levokovitz, Eva Gilboa-Schechtman, Talma Hendler, Eiran Vadim Harel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Ruminative responding involves repetitive and passive thinking about one’s negative affect. This tendency interferes with initiation of goal-directed rewarding strategies, which could alleviate depressive states. Such reward-directed response selection has been shown to be mediated by ventral striatum/nucleus accumbens (VS/NAcc) function. However, to date, no study has examined whether trait rumination relates to VS/NAcc functionality. Here, we tested whether rumination moderates VS/NAcc function both in response to reward and during a ruminative state. Methods: Trait rumination was considered dimensionally using Rumination Response Scale (RRS) scores. Our sample (N = 80) consisted of individuals from a community sample and from patients diagnosed with major depressive disorder, providing a broad range of RRS scores. Participants underwent fMRI to assess two modes of VS/NAcc functionality: 1) in response to reward, and 2) during resting-state, as a proxy for ruminative state. We then tested for associations between RRS scores and VS/NAcc functional profiles, statistically controlling for overall depressive symptom severity. Results: RRS scores correlated positively with VS/NAcc response to reward. Furthermore, we noted that higher RRS scores were associated with increased ruminative-dependent resting-state functional connectivity of the VS/NAcc with the left orbitofrontal cortex. Conclusions: These findings suggest that ruminative tendencies manifest in VS/NAcc reward- and rumination-related functions, providing support for a theoretical-clinical perspective of rumination as a habitual impairment in selection of rewarding, adaptive coping strategies.

Original languageEnglish
Article number67
JournalFrontiers in Psychiatry
Volume11
DOIs
StatePublished - 20 Feb 2020

Bibliographical note

Publisher Copyright:
© Copyright © 2020 Erdman, Abend, Jalon, Artzi, Gazit, Avirame, Ais, Levokovitz, Gilboa-Schechtman, Hendler and Harel.

Keywords

  • depression
  • nucleus accumbens
  • reward
  • rumination
  • ventral striatum

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