Abstract
Reactive oxygen species (ROS) play a multitude of signaling roles in different organisms from bacteria to mammalian cells. They were initially thought to be toxic byproducts of aerobic metabolism, but have now been acknowledged as central players in the complex signaling network of cells. In this review, we will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.
| Original language | English |
|---|---|
| Pages (from-to) | 300-309 |
| Number of pages | 10 |
| Journal | Trends in Plant Science |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2011 |
Bibliographical note
Funding Information:Supported by funding from The National Science Foundation (IBN-0420033, NSF-0431327, IOS-0639964 and IOS-0743954), University of North Texas College of Arts and Sciences, and EU grant FP7 – MARIE CURIE 447, Ghent University (Multidisciplinary Research Partnership ‘Biotechnology for a Sustainable Economy’ project no. 01MRB510W). S.V. is a postdoctoral fellow of the Research Foundation-Flanders. V.B.T. is the recipient of a Marie Curie Intra-European Fellowship for Career Development (PIEF-GA-2008-221427). Work in the laboratory of V.S. was supported in part by the National Science Foundation (NSF) Integrative Organismal Systems (IOS) grant 0820126, NFS Molecular and Cellular Biosciences (MCB) grant 0820823, National Institute of Health (NIH)-National Institute of Allergy and Infectious Diseases (NIAID) grant 2R01AI045774 and NIH National Cancer Institute (NCI) grant R01CA120170. KV is a Postdoctoral Fellows of the Research Foundation-Flanders (FWO) and acknowledges the support of Ghent University (Multidisciplinary Research Partnership “Bioinformatics: from nucleotides to networks”).
Funding
Supported by funding from The National Science Foundation (IBN-0420033, NSF-0431327, IOS-0639964 and IOS-0743954), University of North Texas College of Arts and Sciences, and EU grant FP7 – MARIE CURIE 447, Ghent University (Multidisciplinary Research Partnership ‘Biotechnology for a Sustainable Economy’ project no. 01MRB510W). S.V. is a postdoctoral fellow of the Research Foundation-Flanders. V.B.T. is the recipient of a Marie Curie Intra-European Fellowship for Career Development (PIEF-GA-2008-221427). Work in the laboratory of V.S. was supported in part by the National Science Foundation (NSF) Integrative Organismal Systems (IOS) grant 0820126, NFS Molecular and Cellular Biosciences (MCB) grant 0820823, National Institute of Health (NIH)-National Institute of Allergy and Infectious Diseases (NIAID) grant 2R01AI045774 and NIH National Cancer Institute (NCI) grant R01CA120170. KV is a Postdoctoral Fellows of the Research Foundation-Flanders (FWO) and acknowledges the support of Ghent University (Multidisciplinary Research Partnership “Bioinformatics: from nucleotides to networks”).
| Funders | Funder number |
|---|---|
| NFS Molecular and Cellular Biosciences | |
| Research Foundation-Flanders | |
| University of North Texas College of Arts and Sciences | |
| National Science Foundation | IOS-0743954, IBN-0420033, IOS-0639964, NSF-0431327, 0820126 |
| National Institutes of Health | |
| National Cancer Institute | R01CA120170 |
| National Institute of Allergy and Infectious Diseases | R01AI045774 |
| Division of Molecular and Cellular Biosciences | 0820823 |
| European Commission | FP7 – MARIE CURIE 447 |
| Fonds Wetenschappelijk Onderzoek | |
| Universiteit Gent | PIEF-GA-2008-221427, 01MRB510W |