ROS signaling: The new wave?

Ron Mittler, Sandy Vanderauwera, Nobuhiro Suzuki, Gad Miller, Vanesa B. Tognetti, Klaas Vandepoele, Marty Gollery, Vladimir Shulaev, Frank Van Breusegem

Research output: Contribution to journalReview articlepeer-review

1626 Scopus citations


Reactive oxygen species (ROS) play a multitude of signaling roles in different organisms from bacteria to mammalian cells. They were initially thought to be toxic byproducts of aerobic metabolism, but have now been acknowledged as central players in the complex signaling network of cells. In this review, we will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.

Original languageEnglish
Pages (from-to)300-309
Number of pages10
JournalTrends in Plant Science
Issue number6
StatePublished - Jun 2011

Bibliographical note

Funding Information:
Supported by funding from The National Science Foundation (IBN-0420033, NSF-0431327, IOS-0639964 and IOS-0743954), University of North Texas College of Arts and Sciences, and EU grant FP7 – MARIE CURIE 447, Ghent University (Multidisciplinary Research Partnership ‘Biotechnology for a Sustainable Economy’ project no. 01MRB510W). S.V. is a postdoctoral fellow of the Research Foundation-Flanders. V.B.T. is the recipient of a Marie Curie Intra-European Fellowship for Career Development (PIEF-GA-2008-221427). Work in the laboratory of V.S. was supported in part by the National Science Foundation (NSF) Integrative Organismal Systems (IOS) grant 0820126, NFS Molecular and Cellular Biosciences (MCB) grant 0820823, National Institute of Health (NIH)-National Institute of Allergy and Infectious Diseases (NIAID) grant 2R01AI045774 and NIH National Cancer Institute (NCI) grant R01CA120170. KV is a Postdoctoral Fellows of the Research Foundation-Flanders (FWO) and acknowledges the support of Ghent University (Multidisciplinary Research Partnership “Bioinformatics: from nucleotides to networks”).


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