TY - JOUR
T1 - Role of the thymus in pediatric HIV-1 infection
AU - Kirschner, Denise E.
AU - Mehr, Ramit
AU - Perelson, Alan S.
PY - 1998/6/1
Y1 - 1998/6/1
N2 - Several lines of evidence suggest that HIV-1 is present in the thymus during HIV-1 infection. Precursors to mature CD4+ T lymphocytes develop in the thymus, which suggests that thymic infection may play a role in the CD4+ T-cell decline observed during the course of pediatric HIV-1 infection. We illustrate, through mathematical modeling, the potential effects of thymic infection on the course of pediatric AIDS disease progression. We find that infection in the thymus not only can supplement peripheral infection but can help explain the faster progression in pediatric cases, as well as the early and high viral burden.
AB - Several lines of evidence suggest that HIV-1 is present in the thymus during HIV-1 infection. Precursors to mature CD4+ T lymphocytes develop in the thymus, which suggests that thymic infection may play a role in the CD4+ T-cell decline observed during the course of pediatric HIV-1 infection. We illustrate, through mathematical modeling, the potential effects of thymic infection on the course of pediatric AIDS disease progression. We find that infection in the thymus not only can supplement peripheral infection but can help explain the faster progression in pediatric cases, as well as the early and high viral burden.
KW - AIDS
KW - HIV
KW - Immunology
KW - Mathematical modeling
KW - Ordinary differential equations
KW - Pediatric AIDS
KW - Thymus
UR - http://www.scopus.com/inward/record.url?scp=0032102060&partnerID=8YFLogxK
U2 - 10.1097/00042560-199806010-00001
DO - 10.1097/00042560-199806010-00001
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C2 - 9637574
AN - SCOPUS:0032102060
SN - 1077-9450
VL - 18
SP - 95
EP - 109
JO - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
IS - 2
ER -
