TY - JOUR
T1 - Role of the MAPK cascade in mammalian germ cells
AU - Sun, Q. Y.
AU - Breitbart, H.
AU - Schatten, H.
PY - 2000
Y1 - 2000
N2 - The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation and cell cycle regulation. Since the first report in 1993 of MAPK's involvement in the functional regulation of mammalian oocytes, much work has been done on the role of the MAPK cascade in germ cells in different species of mammals. This review describes the possible involvement of the MOS/MEK/MAPK/RSK cascade in spermatogenesis, sperm function, oocyte meiotic re-initiation, spindle assembly, metaphase II arrest, pronuclear formation and the entry of first mitosis, as well as the cross-talk of this cascade to maturation-promoting factor (MPF) and other signal molecules in mammals.
AB - The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation and cell cycle regulation. Since the first report in 1993 of MAPK's involvement in the functional regulation of mammalian oocytes, much work has been done on the role of the MAPK cascade in germ cells in different species of mammals. This review describes the possible involvement of the MOS/MEK/MAPK/RSK cascade in spermatogenesis, sperm function, oocyte meiotic re-initiation, spindle assembly, metaphase II arrest, pronuclear formation and the entry of first mitosis, as well as the cross-talk of this cascade to maturation-promoting factor (MPF) and other signal molecules in mammals.
KW - Fertilization
KW - MOS
KW - Meiosis
KW - Oocyte maturation
KW - Protein kinase C (PKC)
UR - http://www.scopus.com/inward/record.url?scp=0033770463&partnerID=8YFLogxK
U2 - 10.1071/rd00014
DO - 10.1071/rd00014
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C2 - 11101281
AN - SCOPUS:0033770463
SN - 1031-3613
VL - 11
SP - 443
EP - 450
JO - Reproduction, Fertility and Development
JF - Reproduction, Fertility and Development
IS - 7-8
ER -