Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

S. V. Nikulin; M. P. Raigorodskaya; A. A. Poloznikov; G. S. Zakharova; U. Schumacher; D. Wicklein; C. Stürken; K. Riecken; K. A. Fomicheva; B. Ya Alekseev; M. Yu Shkurnikov

doi:10.1007/s10517-018-4051-8

Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

S. V. Nikulin
, M. P. Raigorodskaya
, A. A. Poloznikov
, G. S. Zakharova
, U. Schumacher
, D. Wicklein
, C. Stürken
, K. Riecken
, K. A. Fomicheva
, B. Ya Alekseev
, M. Yu Shkurnikov

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.

Original language	English
Pages (from-to)	650-654
Number of pages	5
Journal	Bulletin of Experimental Biology and Medicine
Volume	164
Issue number	5
DOIs	https://doi.org/10.1007/s10517-018-4051-8
State	Published - 1 Mar 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Funding

1BioClinicum Center; 2Moscow Institute of Physics and Technology (MIPT); 3P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation, Moscow, Russia; 4University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Address for correspondence: [email protected]. B. Ya. Alekseev The study was supported by the Federal Target Program “Research and Development in Priority Areas of Advancement of the Russian Scientific and Technological Complex for 2014-2020” (RFME-FI61316X0058).

Funders	Funder number
National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Russian Scientific and Technological Complex for 2014-2020	RFME-FI61316X0058
Research and Development

Keywords

IGFBP6
MDA-MB-231
epithelial-mesenchymal transition
metastases
relapse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10517-018-4051-8

Cite this

Nikulin, S. V., Raigorodskaya, M. P., Poloznikov, A. A., Zakharova, G. S., Schumacher, U., Wicklein, D., Stürken, C., Riecken, K., Fomicheva, K. A., Alekseev, B. Y., & Shkurnikov, M. Y. (2018). Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes. Bulletin of Experimental Biology and Medicine, 164(5), 650-654. https://doi.org/10.1007/s10517-018-4051-8

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abstract = "Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.",

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Nikulin, SV, Raigorodskaya, MP, Poloznikov, AA, Zakharova, GS, Schumacher, U, Wicklein, D, Stürken, C, Riecken, K, Fomicheva, KA, Alekseev, BY & Shkurnikov, MY 2018, 'Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes', Bulletin of Experimental Biology and Medicine, vol. 164, no. 5, pp. 650-654. https://doi.org/10.1007/s10517-018-4051-8

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AU - Nikulin, S. V.

AU - Raigorodskaya, M. P.

AU - Poloznikov, A. A.

AU - Zakharova, G. S.

AU - Schumacher, U.

AU - Wicklein, D.

AU - Stürken, C.

AU - Riecken, K.

AU - Fomicheva, K. A.

AU - Alekseev, B. Ya

AU - Shkurnikov, M. Yu

PY - 2018/3/1

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AB - Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.

KW - IGFBP6

KW - MDA-MB-231

KW - epithelial-mesenchymal transition

KW - metastases

KW - relapse

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JF - Bulletin of Experimental Biology and Medicine

IS - 5

ER -

Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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