Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes

S. V. Nikulin, M. P. Raigorodskaya, A. A. Poloznikov, G. S. Zakharova, U. Schumacher, D. Wicklein, C. Stürken, K. Riecken, K. A. Fomicheva, B. Ya Alekseev, M. Yu Shkurnikov

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.

Original languageEnglish
Pages (from-to)650-654
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number5
DOIs
StatePublished - 1 Mar 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Funding

1BioClinicum Center; 2Moscow Institute of Physics and Technology (MIPT); 3P. A. Hertsen Moscow Oncology Research Center, Branch of Branch of National Medical Research Radiology Center of the Ministry of Health of the Russian Federation, Moscow, Russia; 4University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Address for correspondence: [email protected]. B. Ya. Alekseev The study was supported by the Federal Target Program “Research and Development in Priority Areas of Advancement of the Russian Scientific and Technological Complex for 2014-2020” (RFME-FI61316X0058).

FundersFunder number
National Medical Research Radiology Center of the Ministry of Health of the Russian Federation
Russian Scientific and Technological Complex for 2014-2020RFME-FI61316X0058
Research and Development

    Keywords

    • IGFBP6
    • MDA-MB-231
    • epithelial-mesenchymal transition
    • metastases
    • relapse

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