Role of cytokines in heart failure

A. Blum, H. Miller

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Heart failure is a complex neurohumoral and inflammatory syndrome. Studies have shown that proinflammatory cytokines (interleukin-1, interleukin-2, interleukin-6, and tumor necrosis factor) are involved in cardiac depression and in the complex syndrome of heart failure. Understanding the involvement of these cytokines may enable us to reverse cardiac depression and heart failure with the use of monoclonal antibodies directed against specific cytokines that may block the downhill progression of heart failure.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalAmerican Heart Journal
Issue number2 I
StatePublished - 1998
Externally publishedYes


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