Role of activin A in negative regulation of normal and tumor B lymphocytes

D. Zipori, M. Barda-Saad

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45 Scopus citations


Activin A, a member of the transforming growth factor β superfamily, has a wide spread expression pattern and pleiotropic functions. In this overview we summarize data that points to a role of activin A in negative regulation of B lineage lymphocytes. Experiments performed by us and by other groups revealed the capacity of activin A to cause apoptotic death of tumor myeloma cells, through mechanisms of cell cycle inhibition and antagonism with the survival signal of interleukin-6. In vitro studies on B lymphocyte generation from bone marrow stem cells and use of human nasal polyps as a model of inflamed tissue further demonstrate an inhibitory role of activin A in B cell spread and accumulation. These data are analyzed with respect to our model of tissue organization that we term the "restrictin model of cell growth regulation." This model assumes a morphogen-like role of activin A in the hematopoietic system. Thus, the relative concentration of biologically functional activin A, in different parts of the tissue, may determine the local B cell content and functional state of these cells within a specific microenvironment.

Original languageEnglish
Pages (from-to)867-873
Number of pages7
JournalJournal of Leukocyte Biology
Issue number6
StatePublished - Jun 2001
Externally publishedYes


  • IL-6
  • Myeloma
  • Restrictins
  • Signal transduction


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