RNA virus evolution via a fitness-space model

Lev S. Tsimring, Herbert Levine, David A. Kessler

Research output: Contribution to journalArticlepeer-review

208 Scopus citations


We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [I. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841-5844 (1995)] of two distinct stages in the growth of virus fitness.

Original languageEnglish
Pages (from-to)4440-4443
Number of pages4
JournalPhysical Review Letters
Issue number23
StatePublished - 1996


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