TY - JOUR
T1 - RNA virus evolution via a fitness-space model
AU - Tsimring, Lev S.
AU - Levine, Herbert
AU - Kessler, David A.
PY - 1996
Y1 - 1996
N2 - We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [I. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841-5844 (1995)] of two distinct stages in the growth of virus fitness.
AB - We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [I. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841-5844 (1995)] of two distinct stages in the growth of virus fitness.
UR - http://www.scopus.com/inward/record.url?scp=0001444323&partnerID=8YFLogxK
U2 - 10.1103/physrevlett.76.4440
DO - 10.1103/physrevlett.76.4440
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AN - SCOPUS:0001444323
SN - 0031-9007
VL - 76
SP - 4440
EP - 4443
JO - Physical Review Letters
JF - Physical Review Letters
IS - 23
ER -