Silicone gel breast implants and connective tissue disease - A comprehensive review

Eran Bar-Meir, Michael Eherenfeld, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Silicone breast implants have been in use for breast reconstruction and breast augmentation for a long time. In the late 80's anecdotal reports describing a possible association between silicone-gel filled breast implants, and autoimmune diseases was accumulating. Due to the growing concern about the safety of silicone-gel implants, the Food and Drug administration (FDA) restricted their use to participants in controlled clinical trials, including women having reconstructive surgery. However, in recent years, large meta-analyses were unable to establish an association between silicone-gel breast implants and autoimmune disease. We review the current literature, emphasizing the most important epidemiologic studies.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
Issue number4
StatePublished - Jun 2003
Externally publishedYes


  • Autoimmune antibodies
  • Autoimmune disease
  • Breast implants
  • Complications
  • Silicone


Dive into the research topics of 'Silicone gel breast implants and connective tissue disease - A comprehensive review'. Together they form a unique fingerprint.

Cite this