Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck

Dana M. Hartl; Joanne Guerlain; Philippe Gorphe; Madan Kapre; Neeti Kapre Gupta; Nabil F. Saba; K. Thomas Robbins; Ohad Ronen; Juan P. Rodrigo; Primož Strojan; Antti A. Mäkitie; Luiz P. Kowalski; Jatin P. Shah; Alfio Ferlito

doi:10.3390/cancers15194692

Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck

Dana M. Hartl, Joanne Guerlain, Philippe Gorphe, Madan Kapre, Neeti Kapre Gupta, Nabil F. Saba, K. Thomas Robbins, Ohad Ronen, Juan P. Rodrigo, Primož Strojan, Antti A. Mäkitie, Luiz P. Kowalski, Jatin P. Shah, Alfio Ferlito

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.

Original language	English
Article number	4692
Journal	Cancers
Volume	15
Issue number	19
DOIs	https://doi.org/10.3390/cancers15194692
State	Published - Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

chemoradiation
head and neck cancer
salvage surgery
squamous cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers15194692

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Hartl, D. M., Guerlain, J., Gorphe, P., Kapre, M., Kapre Gupta, N., Saba, N. F., Robbins, K. T., Ronen, O., Rodrigo, J. P., Strojan, P., Mäkitie, A. A., Kowalski, L. P., Shah, J. P., & Ferlito, A. (2023). Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck. Cancers, 15(19), Article 4692. https://doi.org/10.3390/cancers15194692

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abstract = "Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.",

keywords = "chemoradiation, head and neck cancer, salvage surgery, squamous cell",

author = "Hartl, {Dana M.} and Joanne Guerlain and Philippe Gorphe and Madan Kapre and {Kapre Gupta}, Neeti and Saba, {Nabil F.} and Robbins, {K. Thomas} and Ohad Ronen and Rodrigo, {Juan P.} and Primo{\v z} Strojan and M{\"a}kitie, {Antti A.} and Kowalski, {Luiz P.} and Shah, {Jatin P.} and Alfio Ferlito",

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year = "2023",

month = oct,

doi = "10.3390/cancers15194692",

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volume = "15",

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AU - Robbins, K. Thomas

AU - Ronen, Ohad

AU - Rodrigo, Juan P.

AU - Strojan, Primož

AU - Mäkitie, Antti A.

AU - Kowalski, Luiz P.

AU - Shah, Jatin P.

AU - Ferlito, Alfio

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AB - Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.

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Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck

Abstract

Bibliographical note

Keywords

UN SDGs

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