Review of Outcomes after Salvage Surgery for Recurrent Squamous Cell Carcinoma of the Head and Neck

Dana M. Hartl, Joanne Guerlain, Philippe Gorphe, Madan Kapre, Neeti Kapre Gupta, Nabil F. Saba, K. Thomas Robbins, Ohad Ronen, Juan P. Rodrigo, Primož Strojan, Antti A. Mäkitie, Luiz P. Kowalski, Jatin P. Shah, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Surgery with adjuvant chemoradiotherapy or chemoradiotherapy is the mainstay in treatment for advanced stage head and neck squamous cell carcinoma; however, locoregional recurrences are frequent. Salvage surgery could be proposed in selected patients to improve local control, disease-free, and overall survival. Factors for improved disease-free and overall survival in patients treated with salvage surgery include age, tumor location, the initial T stage, HPV status, resection margins, and the time elapsing from the initial treatment. Clinical trials with adjuvant therapies have shown promise after salvage surgery in terms of tolerance and response, but clinical guidelines for using these adjuvant treatments are currently lacking. The aim of this review is to present current knowledge concerning the incidence and management of recurrent head and neck squamous cell carcinoma and current data concerning survival and morbidity after salvage surgery.

Original languageEnglish
Article number4692
Issue number19
StatePublished - 23 Sep 2023

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© 2023 by the authors.


  • chemoradiation
  • head and neck cancer
  • salvage surgery
  • squamous cell


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