Reversing B cell aging

Ramit Mehr, Doron Melamed

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms leading to these changes are poorly understood. Recently, we have shown that these changes reflect, at least in part, homeostatic pressures imposed by long-lived B cells that accumulate with aging, and that aging in the B lineage can be reversed upon alteration of B cell homeostasis by depletion. Here we discuss homeostatic causes for B lineage immunosenescence, and the potential for its rejuvenation.

Original languageEnglish
Pages (from-to)438-443
Number of pages6
JournalAging
Volume3
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Aging
  • B cells
  • Immunosenescence
  • Rejuvenation

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