Reversible Ag+-crosslinked DNA hydrogels

Weiwei Guo, Xiu Juan Qi, Ron Orbach, Chun Hua Lu, Lina Freage, Iris Mironi-Harpaz, Dror Seliktar, Huang Hao Yang, Itamar Willner

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag+-stimulated formation of cytosine–Ag+–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag+ ions dissociates the hydrogels into a solution phase.

Original languageEnglish
Pages (from-to)4065-4068
Number of pages4
JournalChemical Communications
Volume50
Issue number31
DOIs
StatePublished - 21 Apr 2014
Externally publishedYes

Funding

FundersFunder number
Seventh Framework Programme318671

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