Revealing instances of coordination among multiple cortical areas

M. Abeles

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Cognitive functions must involve interactions between several (perhaps many) cortical regions. The instances of such interactions may not be tightly time locked to any external cue. Thus averaging over repeated trials of brain activity or its spectrograms may miss these instances. Here, coordinated activity among multiple cortical locations is revealed in ongoing activity with millisecond accuracy without the need for averaging over time or frequencies. This is based on reconstructions of the cortical current dipole amplitudes at multiple points from MEG recordings. In these current dipole traces, instances of brief activity undulations (BAUs) are automatically detected and used to reveal where and when cortical points interact. The article shows that these BAUs truly represent the reorganization of activity at the cortex and are strongly connected to behavior.

Original languageEnglish
Pages (from-to)665-675
Number of pages11
JournalBiological Cybernetics
Volume108
Issue number5
DOIs
StatePublished - Oct 2014

Bibliographical note

Publisher Copyright:
© 2013, The Author(s).

Funding

I thank Dr. Stepen E. Robinson (NIMH) for the SAM software and advice, Dr. Yuval Harpaz and Ms. Hana Arnon for support in obtaining the data. This research was supported in part by I-CORE Program of the Planning and Budgeting Committee and The Israel Science Foundation (Grant No. 51/11).

FundersFunder number
Israel Science Foundation
Israel Science Foundation51/11
Planning and Budgeting Committee of the Council for Higher Education of Israel

    Keywords

    • Binding
    • Cortical current dipoles
    • Higher brain functions
    • MEG

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