Even in the absence of stimulation or task, the cerebral cortex shows an incessant pattern of ultra slow fluctuations which are coherent across brain regions. In the healthy brain these coherent patterns (also termed resting state functional connectivity) often exhibit spatial similarity to the large scale organization of task-induced functional networks. However, it is not clear to what extent the resting state patterns can also reflect task-induced abnormalities in cortical activations which are often detected in various brain pathologies. Here we examined whether an abnormal visual activation pattern is recapitulated in the resting state functional connectivity. We examined LG, a sighted young adult with developmental object agnosia and no apparent cortical structural abnormality. We have previously reported that upon visual stimulation, LG's intermediate visual areas (V2, V3) are paradoxically deactivated. Here, examining LG's resting state functional connectivity revealed the same pattern of functional abnormality - including a strong atypical decorrelation between areas V2-V3 and the rest of the visual system. Thus, our results suggest that resting-state functional connectivity could provide a powerful tool which could complement task-specific paradigms in detecting task-related abnormalities in cortical activity without resorting to task performance.
|Number of pages||10|
|State||Published - 5 Apr 2013|
Bibliographical noteFunding Information:
We would like to thank Michal Harel for her support in brain reconstruction and data analysis. This study was supported by a Marie-Curie IEF fellowship (S.G.-D.), the EU FP7 VERE grant (R.M.), the Helen and Martin Kimmel award (R.M.), the Human Frontier Science Program Organization long-term fellowship (Y.N.), and NIMH grant R01 MH 64458-10 (S.B.).
- Developmental object agnosia
- Intermediate visual areas
- Visual cortex