Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

Evan Elliott; Gili Ezra-Nevo; Limor Regev; Adi Neufeld-Cohen; Alon Chen

doi:10.1038/nn.2642

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

Evan Elliott, Gili Ezra-Nevo, Limor Regev, Adi Neufeld-Cohen, Alon Chen

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

387 Scopus citations

Abstract

DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.

Original language	English
Pages (from-to)	1351-1353
Number of pages	3
Journal	Nature Neuroscience
Volume	13
Issue number	11
DOIs	https://doi.org/10.1038/nn.2642
State	Published - Nov 2010
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by Roberto and Renata Ruhman, Mark Besen and the Pratt Foundation, the Israel Science Foundation, the Legacy Heritage Biomedical Science program of the Israel Science Foundation, the Nella and Leon Benoziyo Center for Neurosciences, the Nella and Leon Benoziyo Center for Neurological Diseases, the Carl and Micaela Einhorn-Dominic Brain Research Institute, the Irwin Green Alzheimer’s Research Fund, and Gerhard and Hannah Bacharach. A.C. is incumbent of the Philip Harris and Gerald Ronson Career Development Chair.

Funding

This work was supported by Roberto and Renata Ruhman, Mark Besen and the Pratt Foundation, the Israel Science Foundation, the Legacy Heritage Biomedical Science program of the Israel Science Foundation, the Nella and Leon Benoziyo Center for Neurosciences, the Nella and Leon Benoziyo Center for Neurological Diseases, the Carl and Micaela Einhorn-Dominic Brain Research Institute, the Irwin Green Alzheimer’s Research Fund, and Gerhard and Hannah Bacharach. A.C. is incumbent of the Philip Harris and Gerald Ronson Career Development Chair.

Funders	Funder number
Carl and Micaela Einhorn-Dominic Brain Research Institute
Irwin Green Alzheimer’s Research Fund
Pratt Foundation
Israel Science Foundation

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abstract = "DNA methylation regulates gene transcription and has been suggested to encode psychopathologies derived from early life stress. We found that methylation regulated the expression of the Crf (also known as Crh) gene and that chronic social stress in adult mice induced long-term demethylation of this genomic region. Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance.",

author = "Evan Elliott and Gili Ezra-Nevo and Limor Regev and Adi Neufeld-Cohen and Alon Chen",

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Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

Abstract

Bibliographical note

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