Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm

B Goudey; Q Wang; D Rawlinson; A Zarnegar; E Kikianty; J Markham; G Macintyre; G Abraham; L Stern; M Inouye; I Haviv

Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm

B Goudey, Q Wang, D Rawlinson, A Zarnegar, E Kikianty, J Markham, G Macintyre, G Abraham, L Stern, M Inouye, I Haviv

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

One of the limiting factors of current genome-wide association studies (GWAS) is the inability of current methods to comprehensively examine SNP interactions for a reasonable sized dataset. It is hypothesised that this limitation is one of the reasons that GWAS studies have not been able to have a greater impact [1, 2]. Many current methods for handling interactions are computationally expensive and do not scale to entire studies. Those methods that do scale often achieve this by pruning their datasets in some manner. This is commonly done by considering only those SNPs that show strong marginal effects, despite the fact that a strongly interacting pair may consist of SNPs with low effects individually.

Original language	American English
Title of host publication	ISMB
State	Published - 2011

Bibliographical note

Place of conference:Austria

Cite this

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title = "Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm",

abstract = "One of the limiting factors of current genome-wide association studies (GWAS) is the inability of current methods to comprehensively examine SNP interactions for a reasonable sized dataset. It is hypothesised that this limitation is one of the reasons that GWAS studies have not been able to have a greater impact [1, 2]. Many current methods for handling interactions are computationally expensive and do not scale to entire studies. Those methods that do scale often achieve this by pruning their datasets in some manner. This is commonly done by considering only those SNPs that show strong marginal effects, despite the fact that a strongly interacting pair may consist of SNPs with low effects individually.",

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T1 - Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm

AU - Goudey, B

AU - Wang, Q

AU - Rawlinson, D

AU - Zarnegar, A

AU - Kikianty, E

AU - Markham, J

AU - Macintyre, G

AU - Abraham, G

AU - Stern, L

AU - Inouye, M

AU - Haviv, I

N1 - Place of conference:Austria

PY - 2011

Y1 - 2011

N2 - One of the limiting factors of current genome-wide association studies (GWAS) is the inability of current methods to comprehensively examine SNP interactions for a reasonable sized dataset. It is hypothesised that this limitation is one of the reasons that GWAS studies have not been able to have a greater impact [1, 2]. Many current methods for handling interactions are computationally expensive and do not scale to entire studies. Those methods that do scale often achieve this by pruning their datasets in some manner. This is commonly done by considering only those SNPs that show strong marginal effects, despite the fact that a strongly interacting pair may consist of SNPs with low effects individually.

AB - One of the limiting factors of current genome-wide association studies (GWAS) is the inability of current methods to comprehensively examine SNP interactions for a reasonable sized dataset. It is hypothesised that this limitation is one of the reasons that GWAS studies have not been able to have a greater impact [1, 2]. Many current methods for handling interactions are computationally expensive and do not scale to entire studies. Those methods that do scale often achieve this by pruning their datasets in some manner. This is commonly done by considering only those SNPs that show strong marginal effects, despite the fact that a strongly interacting pair may consist of SNPs with low effects individually.

UR - https://scholar.google.co.il/scholar?q=Replication+of+epistatic+DNA+loci+in+two+case-control+GWAS+studies+using+OPE+algorithm&btnG=&hl=en&as_sdt=0%2C5

M3 - Conference contribution

BT - ISMB

ER -

Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm

Abstract

Bibliographical note

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