Replication of epistatic DNA loci in two case-control GWAS studies using OPE algorithm

B Goudey, Q Wang, D Rawlinson, A Zarnegar, E Kikianty, J Markham, G Macintyre, G Abraham, L Stern, M Inouye, I Haviv

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


One of the limiting factors of current genome-wide association studies (GWAS) is the inability of current methods to comprehensively examine SNP interactions for a reasonable sized dataset. It is hypothesised that this limitation is one of the reasons that GWAS studies have not been able to have a greater impact [1, 2]. Many current methods for handling interactions are computationally expensive and do not scale to entire studies. Those methods that do scale often achieve this by pruning their datasets in some manner. This is commonly done by considering only those SNPs that show strong marginal effects, despite the fact that a strongly interacting pair may consist of SNPs with low effects individually.
Original languageAmerican English
Title of host publicationISMB
StatePublished - 2011

Bibliographical note

Place of conference:Austria


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