Renal slit diaphragm - The open zipper and the failing heart

Shany Blum, Farid Nakhoul, Eliyahu Khankin, Zaid Abassi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Inherited forms of proteinuria constitute a rare and heterogeneous group of diseases, the most prominent of which is glomerular dysfunction, which leads to proteinuria. Investigation of the genetic background underlying these diseases has provided significant data on the normal operation of the glomerular filter. Among the different components of the glomerulus, the podocyte slit diaphragm is considered the main source for genetically derived protein alteration, which leads in turn to proteinuria. Investigation of the different proteins revealed that the lack of nephrin and podocin is the leading cause of several inherited forms of proteinuria. It was also proposed that the lack of podocin is linked to cardiac anomalies. This review suggests that the absence of slit diaphragm proteins and the open zipper phenomenon are associated with cardiac anomalies.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalIsrael Medical Association Journal
Issue number2
StatePublished - Feb 2007
Externally publishedYes


  • Cardiac anomalies
  • Nephrin
  • Nephrotic syndrome
  • Podocin
  • Slit diaphragm


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