Remote and low-cost intraocular pressure monitoring by deep learning of speckle patterns

Zeev Kalyuzhner, Sergey Agdarov, Yevgeny Beiderman, Aviya Bennet, Yafim Beiderman, Zeev Zalevsky

Research output: Contribution to journalArticlepeer-review


Significance: Glaucoma, a leading cause of global blindness, disproportionately affects low-income regions due to expensive diagnostic methods. Affordable intraocular pressure (IOP) measurement is crucial for early detection, especially in low- and middle-income countries. Aim: We developed a remote photonic IOP biomonitoring method by deep learning of the speckle patterns reflected from an eye sclera stimulated by a sound source. We aimed to achieve precise IOP measurements. Approach: IOP was artificially raised in 24 pig eyeballs, considered similar to human eyes, to apply our biomonitoring method. By deep learning of the speckle pattern videos, we analyzed the data for accurate IOP determination. Results: Our method demonstrated the possibility of high-precision IOP measurements. Deep learning effectively analyzed the speckle patterns, enabling accurate IOP determination, with the potential for global use. Conclusions: The novel, affordable, and accurate remote photonic IOP biomonitoring method for glaucoma diagnosis, tested on pig eyes, shows promising results. Leveraging deep learning and speckle pattern analysis, together with the development of a prototype for human eyes testing, could enhance diagnosis and management, particularly in resource-constrained settings worldwide.

Original languageEnglish
Article number037003
JournalJournal of Biomedical Optics
Issue number3
StatePublished - 1 Mar 2024

Bibliographical note

Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.


  • biomonitoring
  • glaucoma
  • intraocular pressure
  • machine learning
  • photonics
  • remote sensing


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