Release of endogenous cholecystokinin in response to gastric preloads in rats on postnatal days 9-12

Aron Weller; Iris H. Gispan; Robert C. Ritter; Lynne Brenner; Gerard P. Smith

doi:10.1016/s0031-9384(00)00288-2

Release of endogenous cholecystokinin in response to gastric preloads in rats on postnatal days 9-12

Aron Weller, Iris H. Gispan, Robert C. Ritter, Lynne Brenner, Gerard P. Smith

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Release of endogenous cholecystokinin (CCK) from the small intestine by gastric loads was investigated in rats on postnatal days 9-12 (P9-P12). After 5-6 h of deprivation, pups received 5% b.wt. loads of water, 0.9% NaCl, 20% glucose, 20% maltose, 200 mg soybean trypsin inhibitor (SBTI) in 0.9% saline or sham load. Plasma was collected 15 min after the loads, and the concentration of bioactive CCK was measured by a specific and sensitive bioassay. Loads of SBTI and water significantly increased plasma CCK compared to sham loads, but loads of saline, glucose, and maltose did not. The efficacy of the water load was not demonstrated in adult rats. The results suggest that the previously reported reduction of intake during independent ingestion by hypertonic preloads of glucose and maltose was not mediated by the release of CCK sufficient to be detected in the plasma under these conditions.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Physiology and Behavior
Volume	72
Issue number	1-2
DOIs	https://doi.org/10.1016/s0031-9384(00)00288-2
State	Published - Jan 2001

Bibliographical note

Funding Information:
The authors thank Ofra Schwartz for technical assistance and Ms. Laurel A. Torres for processing the manuscript. This research was supported by a grant from the U.S.–Israel Binational Science Foundation. Dr. Ritter was supported by NS20561, and Dr. Smith was supported by MH40010.

Funding

The authors thank Ofra Schwartz for technical assistance and Ms. Laurel A. Torres for processing the manuscript. This research was supported by a grant from the U.S.–Israel Binational Science Foundation. Dr. Ritter was supported by NS20561, and Dr. Smith was supported by MH40010.

Funders	Funder number
U.S.-Israel Binational Science Foundation	MH40010
National Institute of Neurological Disorders and Stroke	R01NS020561

Keywords

Glucose
Independent ingestion
Inhibition of food intake
Maltose
Ontogeny
Soybean trypsin inhibitor
Water intake

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10.1016/s0031-9384(00)00288-2

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title = "Release of endogenous cholecystokinin in response to gastric preloads in rats on postnatal days 9-12",

abstract = "Release of endogenous cholecystokinin (CCK) from the small intestine by gastric loads was investigated in rats on postnatal days 9-12 (P9-P12). After 5-6 h of deprivation, pups received 5% b.wt. loads of water, 0.9% NaCl, 20% glucose, 20% maltose, 200 mg soybean trypsin inhibitor (SBTI) in 0.9% saline or sham load. Plasma was collected 15 min after the loads, and the concentration of bioactive CCK was measured by a specific and sensitive bioassay. Loads of SBTI and water significantly increased plasma CCK compared to sham loads, but loads of saline, glucose, and maltose did not. The efficacy of the water load was not demonstrated in adult rats. The results suggest that the previously reported reduction of intake during independent ingestion by hypertonic preloads of glucose and maltose was not mediated by the release of CCK sufficient to be detected in the plasma under these conditions.",

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note = "Funding Information: The authors thank Ofra Schwartz for technical assistance and Ms. Laurel A. Torres for processing the manuscript. This research was supported by a grant from the U.S.–Israel Binational Science Foundation. Dr. Ritter was supported by NS20561, and Dr. Smith was supported by MH40010.",

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AU - Smith, Gerard P.

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Release of endogenous cholecystokinin in response to gastric preloads in rats on postnatal days 9-12

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Keywords

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