Abstract
Human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma (KS)-associated herpesvirus, is causally implicated in all forms of KS, including the classic form. Our objective was to investigate the relationship between HHV-8 load in peripheral blood mononuclear cells (PBMCs) and the stage of the disease in classic KS (CKS) patients. HHV-8 loads were measured in 41 PBMC samples from CKS patients with different Krigel-based classification stages using a quantitative real-time polymerase chain reaction assay. Low HHV-8 DNA loads reaching a maximum of 75.5 copies/105 cells were detected in 73.2% of the patients. HHV-8 loads in patients with stages I and II were similarly distributed. An increased detection rate of HHV-8 DNA, although not statistically significant, was evident in patients diagnosed with CKS stages III and IV. We conclude that the measurements of HHV-8 load in PBMCs provide a limited correlation with the clinical stage of KS.
| Original language | English |
|---|---|
| Pages (from-to) | 387-392 |
| Number of pages | 6 |
| Journal | Diagnostic Microbiology and Infectious Disease |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2007 |
Bibliographical note
Funding Information:This study was supported by grant no. 6537-6 from the Public Committee for Allocation of Estate Funds, Ministry of Justice, Israel, and by the Israel Cancer Association. We thank Dr Yury Kaminir for statistical analysis.
Funding
This study was supported by grant no. 6537-6 from the Public Committee for Allocation of Estate Funds, Ministry of Justice, Israel, and by the Israel Cancer Association. We thank Dr Yury Kaminir for statistical analysis.
| Funders | Funder number |
|---|---|
| Ministry of Justice, Israel | |
| Israel Cancer Association |
Keywords
- Classic Kaposi sarcoma, CKS
- Human herpesvirus 8, HHV-8
- Kaposi sarcoma, KS
- Kaposi sarcoma-associated herpesvirus (KSHV)
- Viral load
