Relationship between human herpesvirus 8 loads and disease stage in classic Kaposi sarcoma patients

Emma Guttman-Yassky, Rinat Abada, Zipi Kra-Oz, Judith Sattinger, Alex Perelman, Reuven Bergman, Ronit Sarid

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma (KS)-associated herpesvirus, is causally implicated in all forms of KS, including the classic form. Our objective was to investigate the relationship between HHV-8 load in peripheral blood mononuclear cells (PBMCs) and the stage of the disease in classic KS (CKS) patients. HHV-8 loads were measured in 41 PBMC samples from CKS patients with different Krigel-based classification stages using a quantitative real-time polymerase chain reaction assay. Low HHV-8 DNA loads reaching a maximum of 75.5 copies/105 cells were detected in 73.2% of the patients. HHV-8 loads in patients with stages I and II were similarly distributed. An increased detection rate of HHV-8 DNA, although not statistically significant, was evident in patients diagnosed with CKS stages III and IV. We conclude that the measurements of HHV-8 load in PBMCs provide a limited correlation with the clinical stage of KS.

Original languageEnglish
Pages (from-to)387-392
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume57
Issue number4
DOIs
StatePublished - Apr 2007

Bibliographical note

Funding Information:
This study was supported by grant no. 6537-6 from the Public Committee for Allocation of Estate Funds, Ministry of Justice, Israel, and by the Israel Cancer Association. We thank Dr Yury Kaminir for statistical analysis.

Keywords

  • Classic Kaposi sarcoma, CKS
  • Human herpesvirus 8, HHV-8
  • Kaposi sarcoma, KS
  • Kaposi sarcoma-associated herpesvirus (KSHV)
  • Viral load

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