Regulation of adenosine receptors in cultured heart cells

D. El-Ani, K. A. Jacobson, A. Shainberg, J. Solaro, H. E.D.J. Ter Keurs, W. Barry, G. Kessler-Icekson

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    A1 adenosine receptors were studied on heart cells grown in cultures by the radioligand binding technique. Treatments with agents that accelerated heart rate for 3-4 days, caused an increase in the level of adenosine receptors. Treatments that attenuated heart rate, reduced the level of the receptors. Thus, the cardiac cells respond to environmental conditions affecting heart contraction so as to restore the basal rate of heart activity.

    Original languageEnglish
    Pages (from-to)205-215
    Number of pages11
    JournalAdvances in Experimental Medicine and Biology
    Volume382
    DOIs
    StatePublished - 1995

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