Regional cerebral blood flow in patients with mild hypothyroidism

Yodphat Krausz, Nanette Freedman, Hava Lester, J. P. Newman, Gavriel Barkai, Moshe Bocher, Roland Chisin, Omer Bonne

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Emotional and cognitive abnormalities are common in adult hypothyroidism. Few studies, however, have evaluated cerebral perfusion and metabolism in this disorder. The aims of this study were to compare regional cerebral blood flow (rCBF) between hypothyroid patients and healthy subjects and assess flow during the euthyroid state after treatment. Methods: Ten mildly hypothyroid patients, before and after thyroxine treatment, and 10 healthy controls underwent 99mTc-hexamethylpropyleneamine oxime brain SPECT, MRI, and psychometric testing. SPECT images were analyzed using statistical parametric mapping. Results: Compared with controls, rCBF in patients before treatment was lower in right parietooccipital gyri, cuneus, posterior cingulate, lingual gyrus, fusiform, insula, and pre- and postcentral gyri. Perfusion did not normalize on a return to the euthyroid state. Conclusion: Decreased rCBF in mild hypothyroidism is found in regions mediating attention, motor speed, memory, and visuospatial processing, faculties affected in hypothyroidism. Follow-up studies are needed to determine the longer-term persistence of perfusion abnormalities in this disorder.

Original languageEnglish
Pages (from-to)1712-1715
Number of pages4
JournalJournal of Nuclear Medicine
Issue number10
StatePublished - 1 Oct 2004
Externally publishedYes


  • Brain SPECT
  • Cerebral blood flow
  • Cognition
  • Hypothyroidism
  • Mood


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