TY - JOUR
T1 - Reduction in multiresistant nosocomial infections in neonates following substitution of ceftazidime with piperacillin/tazobactam in empiric antibiotic therapy
AU - Flidel-Rimon, O.
AU - Friedman, S.
AU - Gradstein, S.
AU - Bardenstein, R.
AU - Shinwell, E. S.
PY - 2003/10
Y1 - 2003/10
N2 - Aim: To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis. Methods: Suspected sepsis was treated with amikacin together with ceftazidime in 1995-1998 and piperacillin/ tazobactam in 1999-2002. Results: The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p = 0.0001) between the two periods studied. Conclusion: The change from ceftazidime to piperacillin/ tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.
AB - Aim: To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis. Methods: Suspected sepsis was treated with amikacin together with ceftazidime in 1995-1998 and piperacillin/ tazobactam in 1999-2002. Results: The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p = 0.0001) between the two periods studied. Conclusion: The change from ceftazidime to piperacillin/ tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.
KW - 3rd generation cephalosporins
KW - Multidrug-resistant Klebsiella
KW - Nosocomial infection
KW - Piperacillin/ tazobactam
UR - http://www.scopus.com/inward/record.url?scp=0142125325&partnerID=8YFLogxK
U2 - 10.1080/08035250310005297
DO - 10.1080/08035250310005297
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C2 - 14632339
AN - SCOPUS:0142125325
SN - 0803-5253
VL - 92
SP - 1205
EP - 1207
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 10
ER -