Reduction in multiresistant nosocomial infections in neonates following substitution of ceftazidime with piperacillin/tazobactam in empiric antibiotic therapy

O. Flidel-Rimon, S. Friedman, S. Gradstein, R. Bardenstein, E. S. Shinwell

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Aim: To evaluate the effect of a change in antibiotic protocol on pathogens that cause neonatal sepsis. Methods: Suspected sepsis was treated with amikacin together with ceftazidime in 1995-1998 and piperacillin/ tazobactam in 1999-2002. Results: The annual rate for Klebsiella sepsis fell from 2.5 to 0.45 cases per 1000 admission days (p = 0.0001) between the two periods studied. Conclusion: The change from ceftazidime to piperacillin/ tazobactam is associated with a decrease in the incidence of Klebsiella sepsis.

Original languageEnglish
Pages (from-to)1205-1207
Number of pages3
JournalActa Paediatrica, International Journal of Paediatrics
Volume92
Issue number10
DOIs
StatePublished - Oct 2003
Externally publishedYes

Keywords

  • 3rd generation cephalosporins
  • Multidrug-resistant Klebsiella
  • Nosocomial infection
  • Piperacillin/ tazobactam

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