Reduced prepulse inhibition is associated with increased hypnotizability

Pesach Lichtenberg, Ehud Even-Or, Gali Bar, Raz Levin, Aviv Brin, Uriel Heresco-Levy

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Hypnosis involves the manipulation of conscious attentional discrimination. The prepulse inhibition (PPI) paradigm assesses primary unconscious information processing. We investigated the correlation between hypnotizability and PPI of the startle reflex. Forty-eight healthy subjects were evaluated with the Stanford Hypnotic Susceptibility Scale, Form C (SHSS:C) and acoustic PPI. Subjects were divided into low, medium, and high hypnotizable groups. The low-hypnotizable group showed a significantly higher inhibition of the startle response, at lead intervals 60 ms and 120 ms, than did the medium- and high-hypnotizable groups. We conclude that hypnotizability and PPI may be negatively correlated. These findings lend further support for the role of dopaminergic neurotransmission mechanisms in the determination of hypnotizability levels.

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Issue number4
StatePublished - Jun 2008
Externally publishedYes


  • Dopamine
  • Hypnotizability
  • Prepulse inhibition
  • Sensory gating


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