TY - JOUR
T1 - Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients
AU - Ben-Dor, David H.
AU - Zimmerman, Sharon
AU - Sever, Jonathan
AU - Roz, Neta
AU - Apter, Alan
AU - Rehavi, Moshe
AU - Weizman, Abraham
PY - 2007/7
Y1 - 2007/7
N2 - The vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and quantal release of monoamines. In this study, we assessed high affinity [3H]dihydrotetrabenazine binding to platelet VMAT2, in a group of untreated male Tourette's syndrome (TS) patients (age: 8-17.5 years, n = 9) and in a group of age- and sex-matched healthy controls (age: 9-16 years, n = 16). Significantly decreased platelet VMAT2 density (Bmax) (- 23%, p = 0.016) was observed in the TS patients. The affinity (Kd) of the ligand to platelet VMAT2 was similar in both groups. If the lower platelet VMAT2 density also occurred in the brain, it may have serve as an adaptive mechanism geared to decrease dopamine storage in the presynaptic neurons and thereby to attenuate the dopaminergic overactivity and ameliorate the movement disorder.
AB - The vesicular monoamine transporter (VMAT2) plays a major role in the synaptic accumulation and quantal release of monoamines. In this study, we assessed high affinity [3H]dihydrotetrabenazine binding to platelet VMAT2, in a group of untreated male Tourette's syndrome (TS) patients (age: 8-17.5 years, n = 9) and in a group of age- and sex-matched healthy controls (age: 9-16 years, n = 16). Significantly decreased platelet VMAT2 density (Bmax) (- 23%, p = 0.016) was observed in the TS patients. The affinity (Kd) of the ligand to platelet VMAT2 was similar in both groups. If the lower platelet VMAT2 density also occurred in the brain, it may have serve as an adaptive mechanism geared to decrease dopamine storage in the presynaptic neurons and thereby to attenuate the dopaminergic overactivity and ameliorate the movement disorder.
KW - Attention deficit hyperactivity disorder
KW - Obsessive-compulsive disorder (OCD)
KW - Platelet
KW - Tourette's syndrome
KW - Vesicular monoamine transporter 2 (VMAT2)
UR - http://www.scopus.com/inward/record.url?scp=34248589504&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2007.01.002
DO - 10.1016/j.euroneuro.2007.01.002
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C2 - 17344033
AN - SCOPUS:34248589504
SN - 0924-977X
VL - 17
SP - 523
EP - 526
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 8
ER -
