Redox- and metal-directed structural diversification in designed metalloprotein assemblies

Albert Kakkis, Eyal Golub, Tae Su Choi, F. Akif Tezcan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Herein we describe a designed protein building block whose self-assembly behaviour is dually gated by the redox state of disulphide bonds and the identity of exogenous metal ions. This protein construct is shown - through extensive structural and biophysical characterization - to access five distinct oligomeric states, exemplifying how the complex interplay between hydrophobic, metal-ligand, and reversible covalent interactions could be harnessed to obtain multiple, responsive protein architectures from a single building block.

Original languageEnglish
Pages (from-to)6958-6961
Number of pages4
JournalChemical Communications
Volume58
Issue number49
DOIs
StatePublished - 16 Jun 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry

Funding

FundersFunder number
National Institute of General Medical SciencesP30GM133894

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