Red cell filterability in cigarette smokers and its relations to cardiac hypertrophy

Shaul M. Shasha, Hassan Kamal, Batya Kristal, Gaby Galetzky, Nathan Roguin, Tamar Shkolnik

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The relationship among daily cigarette consumption, washed and non-washed RBC filterability time (FT) as an indicator of erythrocyte deformability and echocardiographic left ventricular mass (LVM) were examined in 25 clinically healthy smokers and in 25 non-smoking controls matched for sex and age. FT of non-washed RBC was significantly higher in smokers than in non-smokers (25.2 ± 3.6 vs. 16.8 ± 2.2 min, P < 0.001). A highly significant linear correlation between number of cigarette consumption and FT was found. These differences were not observed when RBC were washed three times with isotonic saline. LVM was significantly greater in smokers (85.5 ± 13.4 g/m2) than in controls (61.8 ± 6.7 m/m2, P < 0.001). A linear correlation between daily cigarette consumption and LVM was observed. A positive relationship between LVM and FT of non-washed RBC was also found. These results demonstrated that LVM is significantly elevated in smokers and is linearly correlated with both cigarette consumption and RBC filtratibility. The increased deformability found in smokers may be a determinant to the cardiac hypertrophy. The association of both elevated LVM and rheological impairment may indicate unfavourable prognosis.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalAtherosclerosis
Volume98
Issue number1
DOIs
StatePublished - 4 Jan 1993
Externally publishedYes

Keywords

  • Cardiac hypertrophy
  • Cigarette smoking
  • Red cell filterability

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