Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis

Catherine M. Olsen; Christopher J. Bain; Susan J. Jordan; Christina M. Nagle; Adèle C. Green; David C. Whiteman; Penelope M. Webb; D. Bowtell; G. Chenevix-Trench; A. Green; A. Defazio; D. Gertig; N. Traficante; S. Moore; J. Hung; S. Fereday; K. Harrap; T. Sadkowsky; A. Mellon; R. Robertson; T. Vanden Bergh; J. Maidens; K. Nattress; Y. E. Chiew; A. Stenlake; H. Sullivan; B. Alexander; P. Ashover; S. Brown; T. Corrish; L. Green; L. Jackman; K. Martin; B. Ranieri; J. White; V. Jayde; L. Bowes; P. Mamers; T. Schmidt; H. Shirley; S. Viduka; H. Tran; S. Bilic; L. Glavinas; A. Proietto; S. Braye; G. Otton; T. Bonaventura; J. Stewart; M. Friedlander; D. Bell; S. Baron-Hay; A. Ferrier; G. Gard; D. Nevell; B. Young; C. Camaris; R. Crouch; L. Edwards; N. Hacker; D. Marsden; G. Robertson; P. Beale; J. Beith; J. Carter; C. Dalrymple; A. Hamilton; R. Houghton; P. Russell; A. Brand; R. Jaworski; P. Harnett; G. Wain; A. Crandon; M. Cummings; K. Horwood; A. Obermair; D. Wyld; J. Nicklin; L. Perrin; B. Ward; M. Davy; C. Hall; T. Dodd; T. Healy; K. Pittman; D. Henderson; S. Hyde; J. Miller; J. Pierdes; P. Blomfield; D. Challis; R. McIntosh; A. Parker; R. Rome; D. Allen; P. Grant; R. Laurie; M. Robbie; D. Healy; T. Jobling; T. Maniolitas; J. McNealage; P. Rogers; B. Susil; A. Veitch; J. Constable; S. Ping Tong; I. Robinson; I. Simpson; K. Phillips; D. Rischin; P. Waring; M. Loughrey; N. O'Callaghan; Bill Murray; V. Billson; S. Galloway; J. Pyman; M. Quinn; I. Hammond; A. McCartney; Y. Leung; I. Haviv; D. Purdie; N. Zeps; P. G. Parsons; N. Hayward

doi:10.1158/1055-9965.EPI-07-0566

Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis

Catherine M. Olsen, Christopher J. Bain, Susan J. Jordan, Christina M. Nagle, Adèle C. Green, David C. Whiteman, Penelope M. Webb, D. Bowtell, G. Chenevix-Trench, A. Green, A. Defazio, D. Gertig, N. Traficante, S. Moore, J. Hung, S. Fereday, K. Harrap, T. Sadkowsky, A. Mellon, R. RobertsonT. Vanden Bergh, J. Maidens, K. Nattress, Y. E. Chiew, A. Stenlake, H. Sullivan, B. Alexander, P. Ashover, S. Brown, T. Corrish, L. Green, L. Jackman, K. Martin, B. Ranieri, J. White, V. Jayde, L. Bowes, P. Mamers, T. Schmidt, H. Shirley, S. Viduka, H. Tran, S. Bilic, L. Glavinas, A. Proietto, S. Braye, G. Otton, T. Bonaventura, J. Stewart, M. Friedlander, D. Bell, S. Baron-Hay, A. Ferrier, G. Gard, D. Nevell, B. Young, C. Camaris, R. Crouch, L. Edwards, N. Hacker, D. Marsden, G. Robertson, P. Beale, J. Beith, J. Carter, C. Dalrymple, A. Hamilton, R. Houghton, P. Russell, A. Brand, R. Jaworski, P. Harnett, G. Wain, A. Crandon, M. Cummings, K. Horwood, A. Obermair, D. Wyld, J. Nicklin, L. Perrin, B. Ward, M. Davy, C. Hall, T. Dodd, T. Healy, K. Pittman, D. Henderson, S. Hyde, J. Miller, J. Pierdes, P. Blomfield, D. Challis, R. McIntosh, A. Parker, R. Rome, D. Allen, P. Grant, R. Laurie, M. Robbie, D. Healy, T. Jobling, T. Maniolitas, J. McNealage, P. Rogers, B. Susil, A. Veitch, J. Constable, S. Ping Tong, I. Robinson, I. Simpson, K. Phillips, D. Rischin, P. Waring, M. Loughrey, N. O'Callaghan, Bill Murray, V. Billson, S. Galloway, J. Pyman, M. Quinn, I. Hammond, A. McCartney, Y. Leung, I. Haviv, D. Purdie, N. Zeps, P. G. Parsons, N. Hayward

Research output: Contribution to journal › Article › peer-review

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Abstract

It remains unclear whether physical activity is associated with epithelial ovarian cancer risk. We therefore examined the association between recreational physical activity and risk of ovarian cancer in a national population-based case-control study in Australia. We also systematically reviewed all the available evidence linking physical activity with ovarian cancer to provide the best summary estimate of the association. The case-control study included women ages 18 to 79 years with a new diagnosis of invasive (n = 1,269) or borderline (n = 311) epithelial ovarian cancer identified through a network of clinics, physicians, and state cancer registries throughout Australia. Controls (n = 1,509) were randomly selected from the national electoral roll and were frequency matched to cases by age and state. For the systematic review, we identified eligible studies using Medline, the ISI Science Citation Index, and manual review of retrieved references, and included all case-control or cohort studies that permitted assessment of an association between physical activity (recreational/ occupational/sedentary behavior) and histologically confirmed ovarian cancer. Meta-analysis was restricted to the subset of these studies that reported on recreational physical activity. In our case-control study, we observed weakly inverse or null associations between recreational physical activity and risk of epithelial ovarian cancer overall. There was no evidence that the effects varied by tumor behavior or histologic subtype. Twelve studies were included in the meta-analysis, which gave summary estimates of 0.79 (95% confidence interval, 0.70-0.85) for case-control studies and 0.81 (95% confidence interval, 0.57-1.17) for cohort studies for the risk of ovarian cancer associated with highest versus lowest levels of recreational physical activity. Thus, pooled results fromobservational studies suggest that a modest inverse association exists between level of recreational physical activity and the risk of ovarian cancer.

Original language	English
Pages (from-to)	2321-2330
Number of pages	10
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	16
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-07-0566
State	Published - 1 Nov 2007
Externally published	Yes

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10.1158/1055-9965.EPI-07-0566

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Olsen, C. M., Bain, C. J., Jordan, S. J., Nagle, C. M., Green, A. C., Whiteman, D. C., Webb, P. M., Bowtell, D., Chenevix-Trench, G., Green, A., Defazio, A., Gertig, D., Traficante, N., Moore, S., Hung, J., Fereday, S., Harrap, K., Sadkowsky, T., Mellon, A., ... Hayward, N. (2007). Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis. Cancer Epidemiology Biomarkers and Prevention, 16(11), 2321-2330. https://doi.org/10.1158/1055-9965.EPI-07-0566

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title = "Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis",

abstract = "It remains unclear whether physical activity is associated with epithelial ovarian cancer risk. We therefore examined the association between recreational physical activity and risk of ovarian cancer in a national population-based case-control study in Australia. We also systematically reviewed all the available evidence linking physical activity with ovarian cancer to provide the best summary estimate of the association. The case-control study included women ages 18 to 79 years with a new diagnosis of invasive (n = 1,269) or borderline (n = 311) epithelial ovarian cancer identified through a network of clinics, physicians, and state cancer registries throughout Australia. Controls (n = 1,509) were randomly selected from the national electoral roll and were frequency matched to cases by age and state. For the systematic review, we identified eligible studies using Medline, the ISI Science Citation Index, and manual review of retrieved references, and included all case-control or cohort studies that permitted assessment of an association between physical activity (recreational/ occupational/sedentary behavior) and histologically confirmed ovarian cancer. Meta-analysis was restricted to the subset of these studies that reported on recreational physical activity. In our case-control study, we observed weakly inverse or null associations between recreational physical activity and risk of epithelial ovarian cancer overall. There was no evidence that the effects varied by tumor behavior or histologic subtype. Twelve studies were included in the meta-analysis, which gave summary estimates of 0.79 (95% confidence interval, 0.70-0.85) for case-control studies and 0.81 (95% confidence interval, 0.57-1.17) for cohort studies for the risk of ovarian cancer associated with highest versus lowest levels of recreational physical activity. Thus, pooled results fromobservational studies suggest that a modest inverse association exists between level of recreational physical activity and the risk of ovarian cancer.",

author = "Olsen, {Catherine M.} and Bain, {Christopher J.} and Jordan, {Susan J.} and Nagle, {Christina M.} and Green, {Ad{\`e}le C.} and Whiteman, {David C.} and Webb, {Penelope M.} and D. Bowtell and G. Chenevix-Trench and A. Green and A. Defazio and D. Gertig and N. Traficante and S. Moore and J. Hung and S. Fereday and K. Harrap and T. Sadkowsky and A. Mellon and R. Robertson and {Vanden Bergh}, T. and J. Maidens and K. Nattress and Chiew, {Y. E.} and A. Stenlake and H. Sullivan and B. Alexander and P. Ashover and S. Brown and T. Corrish and L. Green and L. Jackman and K. Martin and B. Ranieri and J. White and V. Jayde and L. Bowes and P. Mamers and T. Schmidt and H. Shirley and S. Viduka and H. Tran and S. Bilic and L. Glavinas and A. Proietto and S. Braye and G. Otton and T. Bonaventura and J. Stewart and M. Friedlander and D. Bell and S. Baron-Hay and A. Ferrier and G. Gard and D. Nevell and B. Young and C. Camaris and R. Crouch and L. Edwards and N. Hacker and D. Marsden and G. Robertson and P. Beale and J. Beith and J. Carter and C. Dalrymple and A. Hamilton and R. Houghton and P. Russell and A. Brand and R. Jaworski and P. Harnett and G. Wain and A. Crandon and M. Cummings and K. Horwood and A. Obermair and D. Wyld and J. Nicklin and L. Perrin and B. Ward and M. Davy and C. Hall and T. Dodd and T. Healy and K. Pittman and D. Henderson and S. Hyde and J. Miller and J. Pierdes and P. Blomfield and D. Challis and R. McIntosh and A. Parker and R. Rome and D. Allen and P. Grant and R. Laurie and M. Robbie and D. Healy and T. Jobling and T. Maniolitas and J. McNealage and P. Rogers and B. Susil and A. Veitch and J. Constable and {Ping Tong}, S. and I. Robinson and I. Simpson and K. Phillips and D. Rischin and P. Waring and M. Loughrey and N. O'Callaghan and Bill Murray and V. Billson and S. Galloway and J. Pyman and M. Quinn and I. Hammond and A. McCartney and Y. Leung and I. Haviv and D. Purdie and N. Zeps and Parsons, {P. G.} and N. Hayward",

year = "2007",

month = nov,

day = "1",

doi = "10.1158/1055-9965.EPI-07-0566",

language = "אנגלית",

volume = "16",

pages = "2321--2330",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "11",

}

Olsen, CM, Bain, CJ, Jordan, SJ, Nagle, CM, Green, AC, Whiteman, DC, Webb, PM, Bowtell, D, Chenevix-Trench, G, Green, A, Defazio, A, Gertig, D, Traficante, N, Moore, S, Hung, J, Fereday, S, Harrap, K, Sadkowsky, T, Mellon, A, Robertson, R, Vanden Bergh, T, Maidens, J, Nattress, K, Chiew, YE, Stenlake, A, Sullivan, H, Alexander, B, Ashover, P, Brown, S, Corrish, T, Green, L, Jackman, L, Martin, K, Ranieri, B, White, J, Jayde, V, Bowes, L, Mamers, P, Schmidt, T, Shirley, H, Viduka, S, Tran, H, Bilic, S, Glavinas, L, Proietto, A, Braye, S, Otton, G, Bonaventura, T, Stewart, J, Friedlander, M, Bell, D, Baron-Hay, S, Ferrier, A, Gard, G, Nevell, D, Young, B, Camaris, C, Crouch, R, Edwards, L, Hacker, N, Marsden, D, Robertson, G, Beale, P, Beith, J, Carter, J, Dalrymple, C, Hamilton, A, Houghton, R, Russell, P, Brand, A, Jaworski, R, Harnett, P, Wain, G, Crandon, A, Cummings, M, Horwood, K, Obermair, A, Wyld, D, Nicklin, J, Perrin, L, Ward, B, Davy, M, Hall, C, Dodd, T, Healy, T, Pittman, K, Henderson, D, Hyde, S, Miller, J, Pierdes, J, Blomfield, P, Challis, D, McIntosh, R, Parker, A, Rome, R, Allen, D, Grant, P, Laurie, R, Robbie, M, Healy, D, Jobling, T, Maniolitas, T, McNealage, J, Rogers, P, Susil, B, Veitch, A, Constable, J, Ping Tong, S, Robinson, I, Simpson, I, Phillips, K, Rischin, D, Waring, P, Loughrey, M, O'Callaghan, N, Murray, B, Billson, V, Galloway, S, Pyman, J, Quinn, M, Hammond, I, McCartney, A, Leung, Y, Haviv, I, Purdie, D, Zeps, N, Parsons, PG & Hayward, N 2007, 'Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 11, pp. 2321-2330. https://doi.org/10.1158/1055-9965.EPI-07-0566

TY - JOUR

T1 - Recreational physical activity and epithelial ovarian cancer

T2 - A case-control study, systematic review, and meta-analysis

AU - Olsen, Catherine M.

AU - Bain, Christopher J.

AU - Jordan, Susan J.

AU - Nagle, Christina M.

AU - Green, Adèle C.

AU - Whiteman, David C.

AU - Webb, Penelope M.

AU - Bowtell, D.

AU - Chenevix-Trench, G.

AU - Green, A.

AU - Defazio, A.

AU - Gertig, D.

AU - Traficante, N.

AU - Moore, S.

AU - Hung, J.

AU - Fereday, S.

AU - Harrap, K.

AU - Sadkowsky, T.

AU - Mellon, A.

AU - Robertson, R.

AU - Vanden Bergh, T.

AU - Maidens, J.

AU - Nattress, K.

AU - Chiew, Y. E.

AU - Stenlake, A.

AU - Sullivan, H.

AU - Alexander, B.

AU - Ashover, P.

AU - Brown, S.

AU - Corrish, T.

AU - Green, L.

AU - Jackman, L.

AU - Martin, K.

AU - Ranieri, B.

AU - White, J.

AU - Jayde, V.

AU - Bowes, L.

AU - Mamers, P.

AU - Schmidt, T.

AU - Shirley, H.

AU - Viduka, S.

AU - Tran, H.

AU - Bilic, S.

AU - Glavinas, L.

AU - Proietto, A.

AU - Braye, S.

AU - Otton, G.

AU - Bonaventura, T.

AU - Stewart, J.

AU - Friedlander, M.

AU - Bell, D.

AU - Baron-Hay, S.

AU - Ferrier, A.

AU - Gard, G.

AU - Nevell, D.

AU - Young, B.

AU - Camaris, C.

AU - Crouch, R.

AU - Edwards, L.

AU - Hacker, N.

AU - Marsden, D.

AU - Robertson, G.

AU - Beale, P.

AU - Beith, J.

AU - Carter, J.

AU - Dalrymple, C.

AU - Hamilton, A.

AU - Houghton, R.

AU - Russell, P.

AU - Brand, A.

AU - Jaworski, R.

AU - Harnett, P.

AU - Wain, G.

AU - Crandon, A.

AU - Cummings, M.

AU - Horwood, K.

AU - Obermair, A.

AU - Wyld, D.

AU - Nicklin, J.

AU - Perrin, L.

AU - Ward, B.

AU - Davy, M.

AU - Hall, C.

AU - Dodd, T.

AU - Healy, T.

AU - Pittman, K.

AU - Henderson, D.

AU - Hyde, S.

AU - Miller, J.

AU - Pierdes, J.

AU - Blomfield, P.

AU - Challis, D.

AU - McIntosh, R.

AU - Parker, A.

AU - Rome, R.

AU - Allen, D.

AU - Grant, P.

AU - Laurie, R.

AU - Robbie, M.

AU - Healy, D.

AU - Jobling, T.

AU - Maniolitas, T.

AU - McNealage, J.

AU - Rogers, P.

AU - Susil, B.

AU - Veitch, A.

AU - Constable, J.

AU - Ping Tong, S.

AU - Robinson, I.

AU - Simpson, I.

AU - Phillips, K.

AU - Rischin, D.

AU - Waring, P.

AU - Loughrey, M.

AU - O'Callaghan, N.

AU - Murray, Bill

AU - Billson, V.

AU - Galloway, S.

AU - Pyman, J.

AU - Quinn, M.

AU - Hammond, I.

AU - McCartney, A.

AU - Leung, Y.

AU - Haviv, I.

AU - Purdie, D.

AU - Zeps, N.

AU - Parsons, P. G.

AU - Hayward, N.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - It remains unclear whether physical activity is associated with epithelial ovarian cancer risk. We therefore examined the association between recreational physical activity and risk of ovarian cancer in a national population-based case-control study in Australia. We also systematically reviewed all the available evidence linking physical activity with ovarian cancer to provide the best summary estimate of the association. The case-control study included women ages 18 to 79 years with a new diagnosis of invasive (n = 1,269) or borderline (n = 311) epithelial ovarian cancer identified through a network of clinics, physicians, and state cancer registries throughout Australia. Controls (n = 1,509) were randomly selected from the national electoral roll and were frequency matched to cases by age and state. For the systematic review, we identified eligible studies using Medline, the ISI Science Citation Index, and manual review of retrieved references, and included all case-control or cohort studies that permitted assessment of an association between physical activity (recreational/ occupational/sedentary behavior) and histologically confirmed ovarian cancer. Meta-analysis was restricted to the subset of these studies that reported on recreational physical activity. In our case-control study, we observed weakly inverse or null associations between recreational physical activity and risk of epithelial ovarian cancer overall. There was no evidence that the effects varied by tumor behavior or histologic subtype. Twelve studies were included in the meta-analysis, which gave summary estimates of 0.79 (95% confidence interval, 0.70-0.85) for case-control studies and 0.81 (95% confidence interval, 0.57-1.17) for cohort studies for the risk of ovarian cancer associated with highest versus lowest levels of recreational physical activity. Thus, pooled results fromobservational studies suggest that a modest inverse association exists between level of recreational physical activity and the risk of ovarian cancer.

AB - It remains unclear whether physical activity is associated with epithelial ovarian cancer risk. We therefore examined the association between recreational physical activity and risk of ovarian cancer in a national population-based case-control study in Australia. We also systematically reviewed all the available evidence linking physical activity with ovarian cancer to provide the best summary estimate of the association. The case-control study included women ages 18 to 79 years with a new diagnosis of invasive (n = 1,269) or borderline (n = 311) epithelial ovarian cancer identified through a network of clinics, physicians, and state cancer registries throughout Australia. Controls (n = 1,509) were randomly selected from the national electoral roll and were frequency matched to cases by age and state. For the systematic review, we identified eligible studies using Medline, the ISI Science Citation Index, and manual review of retrieved references, and included all case-control or cohort studies that permitted assessment of an association between physical activity (recreational/ occupational/sedentary behavior) and histologically confirmed ovarian cancer. Meta-analysis was restricted to the subset of these studies that reported on recreational physical activity. In our case-control study, we observed weakly inverse or null associations between recreational physical activity and risk of epithelial ovarian cancer overall. There was no evidence that the effects varied by tumor behavior or histologic subtype. Twelve studies were included in the meta-analysis, which gave summary estimates of 0.79 (95% confidence interval, 0.70-0.85) for case-control studies and 0.81 (95% confidence interval, 0.57-1.17) for cohort studies for the risk of ovarian cancer associated with highest versus lowest levels of recreational physical activity. Thus, pooled results fromobservational studies suggest that a modest inverse association exists between level of recreational physical activity and the risk of ovarian cancer.

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U2 - 10.1158/1055-9965.EPI-07-0566

DO - 10.1158/1055-9965.EPI-07-0566

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C2 - 18006921

AN - SCOPUS:38849207429

SN - 1055-9965

VL - 16

SP - 2321

EP - 2330

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 11

ER -

Recreational physical activity and epithelial ovarian cancer: A case-control study, systematic review, and meta-analysis

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