Abstract
Cardio-respiratory phase synchronization has been
studied in healthy subjects for several years, but little is known
about how cardiovascular impairments affect this subtle phenomenon.
In this paper we study data from 874 post-infarction
patients, where heartbeat intervals and respiration were recorded
approximately one week after the index myocardial infarction
event. Calculating the intensity of the first Fourier mode of the
cyclic relative phase differences we find that cardio-respiratory
phase synchronization is decreased in patients with increased
mortality risk or age. However, our analysis also indicates that
data from 30 minutes recordings is insufficient to achieve a
reliable statistics for predicting mortality risk based on phase
synchronization. Therefore, we further develop techniques for
extracting respiratory information from ECG recordings to be
able to use long-term Holter recordings of post-infarction patients
in future studies. We compare breathing-phase reconstructions
based on the amplitude of the R peaks in the ECG or beat-tobeat
time intervals with real respiratory phases. We find that
the reconstruction works better for R peak amplitudes in most
patients. We optimize the respiration-reconstruction algorithm
and show that it works well for a large group of the patients in
our database.
Original language | American English |
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Title of host publication | Proceedings of the 6th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO) 2010 |
State | Published - 2010 |