TY - JOUR
T1 - Recognizing degenerative aging as a treatable medical condition
T2 - Methodology and policy
AU - Stambler, Ilia
N1 - Publisher Copyright:
© 2017 Stambler I.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - It is becoming increasingly clear that in order to accomplish healthy longevity for the population, there is an urgent need for the research and development of effective therapies against degenerative aging processes underlying major aging-related diseases, including heart disease, neurodegenerative diseases, type 2 diabetes, cancer, pulmonary obstructive diseases, as well as aging-related complications and susceptibilities of infectious communicable diseases. Yet, an important incentive for the research and development of such therapies appears to be the development of clinically applicable and scientifically grounded definitions and criteria for the multifactorial degenerative aging process (or "senility" using the existing ICD category), underlying those diseases, as well as for the safety and effectiveness of interventions against it. Such generally agreed definitions and criteria are currently absent. The devising of such criteria is important not only for the sake of their scientific value and their utility for the development of therapeutic solutions for the aging population, but also to comply with and implement major existing national and international programmatic and regulatory requirements. Some methodological suggestions and potential pitfalls for the development of such criteria are examined.
AB - It is becoming increasingly clear that in order to accomplish healthy longevity for the population, there is an urgent need for the research and development of effective therapies against degenerative aging processes underlying major aging-related diseases, including heart disease, neurodegenerative diseases, type 2 diabetes, cancer, pulmonary obstructive diseases, as well as aging-related complications and susceptibilities of infectious communicable diseases. Yet, an important incentive for the research and development of such therapies appears to be the development of clinically applicable and scientifically grounded definitions and criteria for the multifactorial degenerative aging process (or "senility" using the existing ICD category), underlying those diseases, as well as for the safety and effectiveness of interventions against it. Such generally agreed definitions and criteria are currently absent. The devising of such criteria is important not only for the sake of their scientific value and their utility for the development of therapeutic solutions for the aging population, but also to comply with and implement major existing national and international programmatic and regulatory requirements. Some methodological suggestions and potential pitfalls for the development of such criteria are examined.
KW - Aging
KW - Aging-related diseases
KW - Diagnosis
KW - Frailty
KW - Regulation
KW - Senescence
UR - http://www.scopus.com/inward/record.url?scp=85035085779&partnerID=8YFLogxK
U2 - 10.14336/AD.2017.0130
DO - 10.14336/AD.2017.0130
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 28966803
SN - 2152-5250
VL - 8
SP - 583
EP - 589
JO - Aging and Disease
JF - Aging and Disease
IS - 5
ER -