Recent Advances of Novel Proteinoids and Proteinoid Nanoparticles and Their Applications in Biomedicine and Industrial Uses

Michal Kolitz-Domb, Shlomo Margel

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Proteinoids, thermal polymers composed of amino acids, discovered and studied by Fox, spontaneously self-assemble in spherical structures, microspheres, which Fox presented as the protocells of life. Fox's findings opened up a scope of applicable easy-to-make protein-like particles. In recent years, interest in proteinoids has increased among nanobiomedicine research workers. These structures are suitable for biomedical applications, due to their protein-like nature, biocompatibility, non-toxicity and safety. Several new proteinoids made of a specific selection of amino acids were introduced for biomedical and agricultural industries. Several proteinoids include specific additives polymerized within their backbone, providing special chracteristics for a specific application. These proteinoids, their corresponding nanoparticles and their diverse applications are presented here, primarily focusing on proteinoids for cancer diagnostics and therapy, cosmetic and anti-fog proteinoids.

Original languageEnglish
Pages (from-to)1277-1285
Number of pages9
JournalIsrael Journal of Chemistry
Volume58
Issue number12
DOIs
StatePublished - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Anti-fog
  • Fluorescent nanoparticles
  • Nanoparticles for cancer
  • Nanoparticles for cosmetics
  • Proteinoid nanoparticles
  • Retinoic acid

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