Abstract
In early disease stages, biomolecules of interest exist in very low concentrations, presenting a significant challenge for analytical devices and methods. Here, we provide a comprehensive overview of an innovative optical biosensing technology, termed magnetic modulation biosensing (MMB), its biomedical applications, and its ongoing development. In MMB, magnetic beads are attached to fluorescently labeled target molecules. A controlled magnetic force aggregates the magnetic beads and transports them in and out of an excitation laser beam, generating a periodic fluorescent signal that is detected and demodulated. MMB applications include rapid and highly sensitive detection of specific nucleic acid sequences, antibodies, proteins, and protein interactions. Compared with other established analytical methodologies, MMB provides improved sensitivity, shorter processing time, and simpler protocols.
| Original language | English |
|---|---|
| Article number | 4497 |
| Journal | Sensors |
| Volume | 22 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Jun 2022 |
Bibliographical note
Publisher Copyright:© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Funding
Funding: This research was funded by the Israel Science Foundation (grants No. 1142/15 and 2481/19), the Israel Ministry of Science and Technology (grants No. 3-16908, 101790, and 3-14628).
| Funders | Funder number |
|---|---|
| Israel Science Foundation | 2481/19, 1142/15 |
| Ministry of science and technology, Israel | 3-16908, 101790, 3-14628 |
Keywords
- biosensing
- magnetic beads
- magnetic modulation biosensing
- nucleic acids
- protein-protein interactions
- serology
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