Recent Advances in Polyanhydride Based Biomaterials

Arijit Basu, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

This review focusses on recent developments of polyanhydrides, a class of degradable synthetic biopolymers. Polyanhydrides have been used as carriers for controlled delivery of drugs. A polyanhydride copolymer of carboxyphenoxy propane and sebacic acid has been used in Gliadel brain tumor implants for the controlled delivery of carmustine or bis-chloroethylnitrosourea. They are easy and inexpensive to synthesize (especially scale up). However, polyanhydrides possess a short shelf-life. Hydrolytic cleavage and anhydride interchanges lower their molecular weights during storage. One of the highlights in recent developments of polyanhydride chemistry is the discovery of alternating copolymers having extended shelf-life. Other highlights include their applications in biomedical electronics, vaccine delivery, and nano/micro particulate delivery systems. This review examines approaches for polyanhydride synthesis followed by their recent developments in biomedical applications.

Original languageEnglish
Article number1706815
JournalAdvanced Materials
Volume30
Issue number41
DOIs
StatePublished - 11 Oct 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • alternating polyanhydride
  • bioelectronics
  • melt condensation
  • poly(ester-anhydride)
  • polyanhydride
  • vaccine delivery

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